Department of Ear-Nose-Throat, Dongying People's Hospital, Dongying, China.
Department of Oncology, Dongying People's Hospital, Dongying, China.
Acta Otolaryngol. 2020 May;140(5):418-421. doi: 10.1080/00016489.2020.1717610. Epub 2020 Feb 18.
It has been demonstrated that miRNAs play critical roles in the tumorigenesis and progression of various tumors. The purpose of this research was to determine the serum miR-632 levels in patients with laryngeal squamous cell carcinoma (LSCC) and to investigate its diagnostic and prognostic value. We detected serum miR-632 levels in 162 LSCC patients and 42 healthy volunteers. The ROC curve was carried out to determine diagnostic accuracy. We observed that serum miR-632 levels were upregulated in LSCC patients compared with healthy volunteers ( < .01). Subsequent results from ROC indicated that high sensitivity and specificity of serum miR-632 for diagnosing LSCC (area under the curve 0.8828). In addition, it was found that high expressions of serum miR-632 were significantly associated with advanced N stage ( = .020), histological grade ( = .001), and TNM stage ( = .014). Furthermore, patients with higher serum miR-632 expression had a shorter OS and DFS time than those with lower serum miR-632 levels. Our data revealed that serum miR-632 may be a potential noninvasive biomarker which may become a potential diagnostic and prognostic biomarker for LSCC patients.
已经证实，miRNAs 在各种肿瘤的发生和发展中起着关键作用。本研究旨在测定喉鳞状细胞癌（LSCC）患者血清 miR-632 水平，并探讨其诊断和预后价值。我们检测了 162 例 LSCC 患者和 42 例健康志愿者的血清 miR-632 水平。绘制 ROC 曲线以确定诊断准确性。我们观察到 LSCC 患者的血清 miR-632 水平较健康志愿者升高（ < .01）。ROC 的后续结果表明，血清 miR-632 对 LSCC 的诊断具有较高的敏感性和特异性（曲线下面积 0.8828）。此外，还发现血清 miR-632 的高表达与较晚的 N 分期（ = .020）、组织学分级（ = .001）和 TNM 分期（ = .014）显著相关。此外，血清 miR-632 表达较高的患者的 OS 和 DFS 时间短于血清 miR-632 水平较低的患者。我们的数据表明，血清 miR-632 可能是一种潜在的非侵入性生物标志物，可能成为 LSCC 患者潜在的诊断和预后生物标志物。
