Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland.
Tampere Center for Child Health Research, Tampere University, Tampere, the Department of Paediatrics, Tampere University Hospital, 33520 Tampere, Finland.
Nutrients. 2020 Feb 13;12(2):467. doi: 10.3390/nu12020467.
Dermatitis herpetiformis (DH), a cutaneous manifestation of coeliac disease, is characterized by transglutaminase (TG) 3-targeted dermal immunoglobulin A (IgA) deposits. The treatment for DH is the same as for coeliac disease, namely a life-long gluten-free diet. DH patients typically have gluten-dependent circulating autoantibodies targeting TG3 and TG2, and plasma cells secreting such autoantibodies have been detected in the small intestinal mucosa. This study investigates the gluten-responsiveness of intestinal TG3 and TG2 antibody-secreting plasma cells in 16 treated DH patients undergoing a gluten challenge. The frequency of both plasma cell populations increased significantly during the challenge, and their frequency correlated with the corresponding serum autoantibody levels at post-challenge. TG3-specific plasma cells were absent in all 18 untreated coeliac disease patients and seven non-coeliac control subjects on gluten-containing diets. These findings indicate that, in DH, both intestinal TG3- and TG2-antibody secreting plasma cells are gluten-dependent, and that TG3-antibody secreting plasma cells are DH-specific.
疱疹样皮炎（DH）是一种乳糜泻的皮肤表现，其特征是存在针对转谷氨酰胺酶（TG）3 的皮肤免疫球蛋白 A（IgA）沉积。DH 的治疗方法与乳糜泻相同，即终生无麸质饮食。DH 患者通常具有针对 TG3 和 TG2 的依赖于麸质的循环自身抗体，并且已经在小肠黏膜中检测到分泌此类自身抗体的浆细胞。本研究调查了 16 名接受麸质挑战的治疗后 DH 患者中肠 TG3 和 TG2 抗体分泌浆细胞的麸质反应性。在挑战期间，两种浆细胞群体的频率均显着增加，并且它们的频率与挑战后相应的血清自身抗体水平相关。在所有 18 名未经治疗的乳糜泻患者和 7 名接受含麸质饮食的非乳糜泻对照者中，均不存在 TG3 特异性浆细胞。这些发现表明，在 DH 中，肠 TG3 和 TG2 抗体分泌浆细胞均依赖于麸质，并且 TG3 抗体分泌浆细胞是 DH 特异性的。
