Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
The Institute of Occupational and Environmental Health, Guangzhou Medical University, 1 Tianqiang St., Huangpu West Ave., Guangzhou 510620, China.
Int J Environ Res Public Health. 2020 Feb 13;17(4):1201. doi: 10.3390/ijerph17041201.
The purpose of this study was to synthesize the results of previously published observational studies through meta-analysis to clarify the association between smoking and noise-induced hearing loss (NIHL). We searched several databases as of October 2019. Based on the results of heterogeneity analysis ( statistic and statistic), a fixed effect model (for no heterogeneity; test > 0.1 and ≤ 50%) or a random effects model (for heterogeneity) was used to calculate the pooled odds ratios (ORs). We explored the potential dose-response relationship between smoking and NIHL as well. In total, 27 studies involving 30,465 participants were included. Compared with non-smokers, the pooled OR of current smokers was 2.05 (95% Confidence interval (CI): 1.71-2.46), and of former smokers was 1.11 (95% CI: 1.05-1.18). We found a curve linear association between an increasing number of pack-years (packages/day × smoking years) and risk of NIHL. The dose-response meta-analysis suggested that when the number of pack-years was less than fifteen, the risk of NIHL was increasing, and the highest combined OR was 5.25 (95% CI: 2.30-11.96) for pack-years of fifteen. After fifteen pack-years, the pooled OR had a slow decline. Our study indicated that smoking is a risk factor for NIHL. Current smokers have a higher risk than former smokers, and there is a positive dose-response relationship between smoking and NIHL.
本研究旨在通过荟萃分析综合已发表的观察性研究结果，阐明吸烟与噪声性听力损失（NIHL）之间的关联。我们检索了截至 2019 年 10 月的多个数据库。基于异质性分析（统计量和 统计量）的结果，使用固定效应模型（无异质性；检验>0.1 且≤50%）或随机效应模型（有异质性）计算汇总优势比（ORs）。我们还探讨了吸烟与 NIHL 之间潜在的剂量-反应关系。共纳入 27 项研究，涉及 30465 名参与者。与不吸烟者相比，当前吸烟者的汇总 OR 为 2.05（95%置信区间[CI]：1.71-2.46），而前吸烟者的 OR 为 1.11（95% CI：1.05-1.18）。我们发现，随着吸烟包年数（每天包数×吸烟年数）的增加，NIHL 的风险呈曲线线性相关。剂量-反应荟萃分析表明，当吸烟包年数小于 15 时，NIHL 的风险增加，最高合并 OR 为 15 年吸烟包年数时的 5.25（95% CI：2.30-11.96）。超过 15 年吸烟包年后，汇总 OR 呈缓慢下降趋势。我们的研究表明，吸烟是 NIHL 的一个危险因素。当前吸烟者的风险高于前吸烟者，且吸烟与 NIHL 之间存在正剂量-反应关系。
