Women's Clinic at Lillehammer Hospital, Innlandet Hospital Trust, 2629 Lillehammer, Norway.
Department of Medical Microbiology, Innlandet Hospital Trust, 2629 Lillehammer, Norway.
Biomolecules. 2020 Feb 13;10(2):295. doi: 10.3390/biom10020295.
Mild to moderate iodine deficiency is common among women of childbearing age. Data on iodine status in infants are sparse, partly due to the challenges in collecting urine. Urinary iodine concentration (UIC) is considered a good marker for recent dietary iodine intake and status in populations. The aim of this study was to investigate the reliability of iodine concentration measured in two spot-samples from the same day of diaper-retrieved infant urine and in their mothers' breastmilk. We collected urine and breastmilk from a sample of 27 infants and 25 mothers participating in a cross-sectional study at two public healthcare clinics in Norway. The reliability of iodine concentration was assessed by calculating the intraclass correlation coefficients (ICC) and the coefficient of variation (CV). The ICC for infants' urine was 0.64 (95% confidence interval (CI) 0.36-0.82), while the ICC for breastmilk was 0.83 (95% CI 0.65-0.92) Similarly, the intraindividual CV for UIC was 0.25 and 0.14 for breastmilk iodine concentration (BIC). Compared to standard methods of collecting urine for measuring iodine concentration, the diaper-pad collection method does not substantially affect the reliability of the measurements.
轻至中度碘缺乏症在育龄妇女中较为常见。关于婴儿碘状况的数据较为匮乏，部分原因是收集尿液存在困难。尿碘浓度（UIC）被认为是人群近期碘摄入量和碘营养状况的良好指标。本研究旨在探讨同日收集的两份尿布回收婴儿尿液和其母亲母乳中碘浓度的可靠性。我们从挪威两家公立医疗诊所的 27 名婴儿和 25 名母亲的横断面研究中收集了尿液和母乳。通过计算组内相关系数（ICC）和变异系数（CV）评估碘浓度的可靠性。婴儿尿液的 ICC 为 0.64（95%置信区间 0.36-0.82），而母乳的 ICC 为 0.83（95%置信区间 0.65-0.92）。同样，UIC 的个体内 CV 为 0.25，母乳碘浓度（BIC）的个体内 CV 为 0.14。与用于测量碘浓度的标准尿液收集方法相比，尿布垫收集方法不会显著影响测量的可靠性。
