Department of Activity and Health, and Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden.
Department of Acute Internal Medicine and Geriatrics, Department of Social and Welfare Studies, Linköping University, Linköping, Sweden.
Clin Rehabil. 2020 Apr;34(4):533-544. doi: 10.1177/0269215520907669. Epub 2020 Feb 19.
To evaluate a group-based music intervention in patients with Parkinson's disease.
Parallel group randomized controlled trial with qualitative triangulation.
Neurorehabilitation in primary care.
Forty-six patients with Parkinson's disease were randomized into intervention group ( = 26), which received training with the music-based intervention, and control group ( = 20) without training.
The intervention was delivered twice weekly for 12 weeks.
Primary outcome was Timed-Up-and-Go subtracting serial 7's (dual-task ability). Secondary outcomes were cognition, balance, concerns about falling, freezing of gait, and quality of life. All outcomes were evaluated at baseline, post-intervention, and three months post-intervention. Focus groups and individual interviews were conducted with the intervention group and with the delivering physiotherapists.
No between-group differences were observed for dual-task ability. Between-group differences were observed for Falls Efficacy Scale (mean difference (MD) = 6.5 points; 95% confidence interval (CI) = 3.0 to 10.0, = 0.001) and for Parkinson Disease Questionnaire-39 items (MD = 8.3; 95% CI = 2.7 to 13.8, = 0.005) when compared to the control group post-intervention, but these were not maintained at three months post-intervention. Three themes were derived from the interviews: , and .
Patient-reported outcomes and interviews suggest that the group-based music intervention adds value to mood, alertness, and quality of life in patients with Parkinson's disease. The study does not support the efficacy in producing immediate or lasting gains in dual-tasking, cognition, balance, or freezing of gait.
评估基于小组的音乐干预对帕金森病患者的效果。
平行组随机对照试验，结合定性三角测量。
初级保健中的神经康复。
46 名帕金森病患者被随机分为干预组（ = 26），接受基于音乐的干预训练，对照组（ = 20）不接受训练。
干预每周进行两次，持续 12 周。
主要结局是减去连续 7 的计时起立行走测试（双重任务能力）。次要结局是认知、平衡、跌倒担忧、冻结步态和生活质量。所有结局均在基线、干预后和干预后三个月进行评估。对干预组和实施物理治疗师进行了焦点小组和个人访谈。
在双重任务能力方面，两组间无差异。干预后，跌倒效能量表（平均差异（MD） = 6.5 分；95%置信区间（CI） = 3.0 至 10.0， = 0.001）和帕金森病问卷-39 项（MD = 8.3；95% CI = 2.7 至 13.8， = 0.005）方面，干预组优于对照组，但这些差异在干预后三个月时未得到维持。从访谈中得出了三个主题：音乐、小组和个体。
患者报告的结果和访谈表明，基于小组的音乐干预可改善帕金森病患者的情绪、警觉性和生活质量。该研究不支持该干预措施在双重任务、认知、平衡或冻结步态方面立即或长期产生效果。
