University of Girona, Spain.
Parc Sanitari Sant Joan de Déu, Barcelona, Spain.
J Atten Disord. 2021 Aug;25(10):1352-1361. doi: 10.1177/1087054720903372. Epub 2020 Feb 20.
To determine the relationship between treatment duration and the efficacy of pharmacological treatment for reducing ADHD symptoms. We conducted a systematic review of randomized, double-blind, placebo-controlled clinical trials investigating the efficacy of pharmacological interventions in patients with ADHD. The last bibliographic search was performed in April 15, 2019. The effect of treatment duration on efficacy was studied using meta-regression. A total of 87 studies lasting from 3 to 28 weeks were included. Pharmacological treatment improved ADHD symptom severity by -7.35 points. Treatment duration did not moderate the efficacy of pharmacological treatment. Consistent results were found for psychostimulant drugs, methylphenidate, amphetamine derivatives, atomoxetine, and α2-agonists. A negative correlation was found between baseline ADHD severity efficacy (Coefficient = -.250, = .013). The efficacy of pharmacological treatment for ADHD remains stable over time. A greater efficacy in more severe patients is suggested.
为了确定治疗持续时间与药物治疗降低 ADHD 症状的疗效之间的关系。我们对随机、双盲、安慰剂对照的临床试验进行了系统评价，这些试验调查了药物干预对 ADHD 患者的疗效。最后一次文献检索是在 2019 年 4 月 15 日进行的。使用荟萃回归研究了治疗持续时间对疗效的影响。共纳入了 87 项持续时间为 3 至 28 周的研究。药物治疗使 ADHD 症状严重程度降低了-7.35 分。治疗持续时间并没有调节药物治疗的疗效。在兴奋剂药物、哌醋甲酯、苯丙胺衍生物、托莫西汀和α2-激动剂方面都得到了一致的结果。在 ADHD 严重程度疗效的基线（Coefficient = -.250, =.013）上发现了负相关。药物治疗对 ADHD 的疗效随时间保持稳定。提示在病情更严重的患者中疗效更好。
