Antibiotic treatment and selection for mutations in patients with active tuberculosis disease.
作者信息
Vargas Roger, Farhat Maha R
机构信息
Department of Systems Biology, Harvard Medical School, Boston, MA 02115;
Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115.
出版信息
Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):3910-3912. doi: 10.1073/pnas.1920788117. Epub 2020 Feb 19.
Abstract
摘要
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Common Variants in the Glycerol Kinase Gene Reduce Tuberculosis Drug Efficacy.甘油激酶基因常见变异降低结核病药物疗效。
mBio. 2019 Jul 30;10(4):e00663-19. doi: 10.1128/mBio.00663-19.
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Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from culture.直接从痰液中对结核分枝杆菌进行全基因组测序比从培养物中测序能识别出更多的遗传多样性。
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A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.结核分枝杆菌的化学遗传学筛选鉴定出无体内疗效的碳源依赖性生长抑制剂。
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