• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Antibiotic treatment and selection for mutations in patients with active tuberculosis disease.活动性结核病患者的抗生素治疗及突变选择
Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):3910-3912. doi: 10.1073/pnas.1920788117. Epub 2020 Feb 19.
2
Reply to Vargas and Farhat: mutants in human tuberculosis.对瓦尔加斯和法哈特的回复：人类结核病中的突变体
Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):3913-3914. doi: 10.1073/pnas.1922199117. Epub 2020 Feb 19.
3
Genomic Insight into Mechanisms of Reversion of Antibiotic Resistance in Multidrug Resistant Induced by a Nanomolecular Iodine-Containing Complex FS-1.纳米分子碘复合物FS-1诱导多药耐药菌抗生素耐药性逆转机制的基因组学洞察
Front Cell Infect Microbiol. 2017 May 8;7:151. doi: 10.3389/fcimb.2017.00151. eCollection 2017.
4
Mycobacterium tuberculosis isolates from Rio de Janeiro reveal unusually low correlation between pyrazinamide resistance and mutations in the pncA gene.里约热内卢分枝杆菌分离株显示吡嗪酰胺耐药性与 pncA 基因突变之间的相关性非常低。
Infect Genet Evol. 2013 Oct;19:1-6. doi: 10.1016/j.meegid.2013.06.008. Epub 2013 Jun 14.
5
Correlating rrs and eis promoter mutations in clinical isolates of Mycobacterium tuberculosis with phenotypic susceptibility levels to the second-line injectables.将结核分枝杆菌临床分离株中rrs和eis启动子突变与对二线注射剂的表型药敏水平相关联。
Int J Mycobacteriol. 2016 Mar;5(1):1-6. doi: 10.1016/j.ijmyco.2015.09.001. Epub 2015 Oct 1.
6
Frequency of rrs and rpsL mutations in streptomycin-resistant Mycobacterium tuberculosis isolates from Iranian patients.伊朗患者耐链霉素结核分枝杆菌分离株中 rrs 和 rpsL 突变的频率。
J Glob Antimicrob Resist. 2017 Jun;9:51-56. doi: 10.1016/j.jgar.2017.01.005. Epub 2017 Apr 9.
7
[Intensive therapy of patients with pulmonary tuberculosis].[肺结核患者的强化治疗]
Voen Med Zh. 2002 May;323(5):22-6, 112.
8
Effect of Mutations on the Binding of Kanamycin-B to RNA Hairpins Derived from the Mycobacterium tuberculosis Ribosomal A-Site.突变对卡那霉素B与源自结核分枝杆菌核糖体A位点的RNA发夹结合的影响。
Biochemistry. 2015 Dec 29;54(51):7425-37. doi: 10.1021/acs.biochem.5b00710. Epub 2015 Dec 17.
9
Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis.对沙门氏菌利福平耐药突变进行全面表型特征分析，深入了解结核分枝杆菌耐药性的进化。
J Antimicrob Chemother. 2015 Mar;70(3):680-5. doi: 10.1093/jac/dku434. Epub 2014 Oct 31.
10
[Resistance pattern of Mycobacterium tuberculosis (H 37 Rv) to a new antibiotic, lividomycin].[结核分枝杆菌（H 37 Rv）对新型抗生素青紫霉素的耐药模式]
Kekkaku. 1972 Apr;47(4):63-7.

引用本文的文献

1
Mycobacterium bovis frd operon phase variation hijacks succinate signaling to drive immunometabolic rewiring and pathogenicity.牛分枝杆菌frd操纵子的相位变异利用琥珀酸信号传导来驱动免疫代谢重编程和致病性。
Nat Commun. 2025 Jul 16;16(1):6538. doi: 10.1038/s41467-025-61824-9.
2
Verification of emerging genomic mutations in Mycobacterium tuberculosis allows transmission chains to be distinguished in an epidemiological typing cluster extending over thirty years.对结核分枝杆菌新出现的基因组突变进行验证，能够在一个跨越三十年的流行病学分型集群中区分传播链。
PLoS One. 2025 Jun 18;20(6):e0319630. doi: 10.1371/journal.pone.0319630. eCollection 2025.
3
Phase variation as a major mechanism of adaptation in complex.相变异作为复杂适应的主要机制。
Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2301394120. doi: 10.1073/pnas.2301394120. Epub 2023 Jul 3.
4
Aldehyde accumulation in with defective proteasomal degradation results in copper sensitivity.蛋白体降解缺陷导致 中醛类物质积累，从而引起铜敏感性。
mBio. 2023 Aug 31;14(4):e0036323. doi: 10.1128/mbio.00363-23. Epub 2023 Jun 23.
5
Emergence of Canonical and Noncanonical Genomic Variants following Exposure of Clinical Mycobacterium tuberculosis Strains to Bedaquiline or Clofazimine.临床结核分枝杆菌菌株暴露于贝达喹啉或氯法齐明后，典型和非典型基因组变异的出现。
Antimicrob Agents Chemother. 2023 Apr 18;67(4):e0136822. doi: 10.1128/aac.01368-22. Epub 2023 Mar 9.
6
functional genetic diversity, altered drug sensitivity, and precision medicine.功能遗传多样性、药物敏感性改变和精准医学。
Front Cell Infect Microbiol. 2022 Oct 3;12:1007958. doi: 10.3389/fcimb.2022.1007958. eCollection 2022.
7
Understanding the contribution of metabolism to drug tolerance.理解代谢对药物耐受性的贡献。
Front Cell Infect Microbiol. 2022 Aug 22;12:958555. doi: 10.3389/fcimb.2022.958555. eCollection 2022.
8
A critical evaluation of pangenomics, with reference to its utility in outbreak investigation.泛基因组学的批判性评估，及其在疫情调查中的实用性参考。
Microb Genom. 2022 Jun;8(6). doi: 10.1099/mgen.0.000839.
9
The Neglected Contribution of Streptomycin to the Tuberculosis Drug Resistance Problem.链霉素对结核病耐药问题的被忽视的贡献。
Genes (Basel). 2021 Dec 17;12(12):2003. doi: 10.3390/genes12122003.
10
Heterogeneous Streptomycin Resistance Level Among Strains From the Same Transmission Cluster.来自同一传播集群的菌株中链霉素耐药水平存在异质性。
Front Microbiol. 2021 Jun 11;12:659545. doi: 10.3389/fmicb.2021.659545. eCollection 2021.

本文引用的文献

1
Phase variation in produces transiently heritable drug tolerance.产生短暂遗传药物耐受性的相位变化。
Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19665-19674. doi: 10.1073/pnas.1907631116. Epub 2019 Sep 5.
2
Common Variants in the Glycerol Kinase Gene Reduce Tuberculosis Drug Efficacy.甘油激酶基因常见变异降低结核病药物疗效。
mBio. 2019 Jul 30;10(4):e00663-19. doi: 10.1128/mBio.00663-19.
3
Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from culture.直接从痰液中对结核分枝杆菌进行全基因组测序比从培养物中测序能识别出更多的遗传多样性。
BMC Genomics. 2019 May 20;20(1):389. doi: 10.1186/s12864-019-5782-2.
4
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.结核分枝杆菌的化学遗传学筛选鉴定出无体内疗效的碳源依赖性生长抑制剂。
Nat Commun. 2010 Aug 24;1(5):57. doi: 10.1038/ncomms1060.

Antibiotic treatment and selection for mutations in patients with active tuberculosis disease.

作者信息

Vargas Roger, Farhat Maha R

机构信息

Department of Systems Biology, Harvard Medical School, Boston, MA 02115;

Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115.

出版信息

Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):3910-3912. doi: 10.1073/pnas.1920788117. Epub 2020 Feb 19.

DOI:10.1073/pnas.1920788117
PMID:32075922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7049102/
Abstract
摘要