Zhang Yanhong, Zhang Yaxin, Li Yun, Chan Piu, Ma Lina
Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Department of Geriatrics, Neurology and Neurobiology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, 100053, China.
Ther Adv Chronic Dis. 2020 Feb 5;11:2040622320904278. doi: 10.1177/2040622320904278. eCollection 2020.
Frailty is one of the most important risk factors for adverse outcomes in older adults. Despite a high prevalence, there is still a lack of frailty screening instruments specific to Chinese older adults. We developed a simple frailty screening questionnaire (FSQ) that could predict long-term mortality. We aimed to explore the reliability and construct validity of this new measurement tool.
A total of 205 individuals aged 65 years or older were recruited in this study. The FSQ and frailty phenotype were assessed. The FSQ included self-reported slowness, weakness, weight loss, inactivity, and exhaustion. A subgroup of 109 participants completed the FSQ a second time 2 weeks later for test-retest reliability. Frailty phenotype included slowness, exhaustion, weight loss, weakness, and inactivity.
The intraclass correlation coefficient for the FSQ, slowness, weakness, weight loss, inactivity and exhaustion were 0.937, 0.938, 0.934, 0.921, 0.826, and 0.832, respectively. Using a cut-off of 3, the sensitivity, specificity, and area under the curve of the receiver operating characteristic were 52.6%, 93.5%, and 0.883 ( < 0.001), respectively. The kappa coefficient between the FSQ and frailty phenotype was 0.431 ( < 0.001). FSQ score was negatively correlated with walking speed and grip strength, and positively correlated with age. Frailty defined by the FSQ was associated with older age, chronic diseases, and worse physical function.
The FSQ is a potentially useful, reliable, and valid instrument in screening frailty in older adults, and can be recommended to identify frailty in clinical settings.
衰弱是老年人不良结局的最重要风险因素之一。尽管患病率很高，但仍缺乏针对中国老年人的衰弱筛查工具。我们开发了一种简单的衰弱筛查问卷（FSQ），它可以预测长期死亡率。我们旨在探讨这种新测量工具的信度和结构效度。
本研究共招募了205名65岁及以上的个体。对FSQ和衰弱表型进行评估。FSQ包括自我报告的行动迟缓、虚弱、体重减轻、活动减少和疲惫。109名参与者组成的一个亚组在2周后再次完成FSQ以进行重测信度评估。衰弱表型包括行动迟缓、疲惫、体重减轻、虚弱和活动减少。
FSQ、行动迟缓、虚弱、体重减轻、活动减少和疲惫的组内相关系数分别为0.937、0.938、0.934、0.921、0.826和0.832。采用截断值为3时，受试者工作特征曲线的灵敏度、特异度和曲线下面积分别为52.6%、93.5%和0.883（P<0.001）。FSQ与衰弱表型之间的kappa系数为0.431（P<0.001）。FSQ评分与步行速度和握力呈负相关，与年龄呈正相关。FSQ定义的衰弱与年龄较大、慢性疾病和较差的身体功能相关。
FSQ是一种在筛查老年人衰弱方面潜在有用、可靠且有效的工具，可推荐在临床环境中用于识别衰弱。
