From the Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (C.P.-M.).
Icahn School of Medicine at Mount Sinai, New York (C.P.-M., Z.A.F., W.J.M.M.).
Arterioscler Thromb Vasc Biol. 2020 Apr;40(4):865-873. doi: 10.1161/ATVBAHA.119.313455. Epub 2020 Feb 6.
The immune system's role in atherosclerosis has long been an important research topic and is increasingly investigated for therapeutic and diagnostic purposes. Therefore, noninvasive imaging of hematopoietic organs and immune cells will undoubtedly improve atherosclerosis phenotyping and serve as a monitoring method for immunotherapeutic treatments. Among the available imaging techniques, positron emission tomography's unique features make it an ideal tool to quantitatively image the immune response in the context of atherosclerosis and afford reliable readouts to guide medical interventions in cardiovascular disease. Here, we summarize the state of the art in the field of atherosclerosis positron emission tomography immunoimaging and provide an outlook on current and future applications.
免疫系统在动脉粥样硬化中的作用一直是一个重要的研究课题，并且越来越多地被用于治疗和诊断目的。因此，造血器官和免疫细胞的非侵入性成像无疑将改善动脉粥样硬化表型，并作为免疫治疗的监测方法。在现有的成像技术中，正电子发射断层扫描的独特特征使其成为定量成像动脉粥样硬化背景下免疫反应的理想工具，并提供可靠的读数来指导心血管疾病的医学干预。在这里，我们总结了动脉粥样硬化正电子发射断层扫描免疫成像领域的最新技术，并展望了当前和未来的应用。
