Research Center of Traditional Chinese Medicine, the Affiliated Hospital to Changchun Univ. of Chinese Medicine, 1478 Gongnong St., Changchun, Jilin Province, 130021, P. R. China.
Center of Preventive Treatment of Diseases, the Affiliated Hospital to Changchun Univ. of Chinese Medicine, 1478 Gongnong St., Changchun, Jilin Province, 130021, P. R. China.
J Food Sci. 2020 Mar;85(3):576-581. doi: 10.1111/1750-3841.15071. Epub 2020 Feb 20.
Elevated free fatty acids may impair insulin-mediated signaling to eNOS that contributes to the pathophysiology of endothelial dysfunction. Previous studies have indicated the protective effect of ginseng and the regulatory potential of phenolic acid components from other plants on endothelial function. Therefore, this study investigated the protective effects of phenolic acid extract from ginseng (PG2) on endothelial cells against palmitate-induced damage. We found that PG2 increases cell viability, inhibits the palmitate-induced intracellular accumulation of lipids, and the overexpression of endothelin-1 (ET-1) through enhancing the phosphorylation of the phosphatidylinositol 3-kinase/Akt/endothelial nitric oxide synthase (PI3K/Akt/eNOS) signaling pathway. The results of this study may be valuable for the development of PG2 to combat the endothelial cell damage caused by hyperlipidemia. PRACTICAL APPLICATION: We proved that phenolic acid extract from ginseng has a protective effect on free fatty acid-induced endothelial dysfunction in vitro. This study provides experimental data for the application of ginseng-derived phenolic acids in treating cardiovascular disease.
升高的游离脂肪酸可能会损害胰岛素介导的内皮型一氧化氮合酶信号转导，从而导致内皮功能障碍的病理生理学改变。先前的研究表明，人参中的人参酚酸和其他植物中的酚酸成分具有保护作用，可以调节内皮功能。因此，本研究调查了人参酚酸提取物（PG2）对棕榈酸诱导的内皮细胞损伤的保护作用。我们发现，PG2 通过增强磷脂酰肌醇 3-激酶/蛋白激酶 B/内皮型一氧化氮合酶（PI3K/Akt/eNOS）信号通路的磷酸化，增加细胞活力，抑制棕榈酸诱导的细胞内脂质积累和内皮素-1（ET-1）的过度表达。这项研究的结果可能对开发 PG2 以对抗高血脂引起的内皮细胞损伤具有重要价值。实际应用：我们证明了人参中的酚酸提取物对体外游离脂肪酸诱导的内皮功能障碍具有保护作用。本研究为人参衍生的酚酸类物质在治疗心血管疾病中的应用提供了实验数据。
