• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

冷大气等离子体和金量子点通过细胞受体激活的凋亡途径对胶质母细胞瘤细胞发挥双重细胞毒性作用。

Cold Atmospheric Plasma and Gold Quantum Dots Exert Dual Cytotoxicity Mediated by the Cell Receptor-Activated Apoptotic Pathway in Glioblastoma Cells.

作者信息

Kaushik Nagendra Kumar, Kaushik Neha, Wahab Rizwan, Bhartiya Pradeep, Linh Nguyen Nhat, Khan Farheen, Al-Khedhairy Abdulaziz A, Choi Eun Ha

机构信息

Plasma Bioscience Research Center/Applied Plasma Medicine Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul 01897, Korea.

Department of Laboratory Medicine, College of Medicine, Hanyang University, Guri 11923, Korea.

出版信息

Cancers (Basel). 2020 Feb 16;12(2):457. doi: 10.3390/cancers12020457.

DOI:10.3390/cancers12020457
PMID:32079108
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7072464/
Abstract

Brain cancer malignancies represent an immense challenge for research and clinical oncology. Glioblastoma is the most lethal form of primary malignant brain cancer and is one of the most aggressive forms commonly associated with adverse prognosis and fatal outcome. Currently, combinations of inorganic and organic nanomaterials have been shown to improve survival rates through targeted drug delivery systems. In this study, we developed a dual treatment approach using cold atmospheric plasma (CAP) and gold quantum dots (AuQDs) for brain cancer. Our results showed that CAP and AuQDs induced dual cytotoxicity in brain cancer cells via Fas/TRAIL-mediated cell death receptor pathways. Moreover, combination treatment with CAP and AuQDs suppressed the motility and sphere-formation of brain cancer cells, which are recognized indicators of cancer aggressiveness. Taken together, the application of AuQDs can improve the efficiency of CAP against brain cancer cells, posing an excellent opportunity for advancing the treatment of aggressive glioblastomas.

摘要

脑癌恶性肿瘤对研究和临床肿瘤学来说是一项巨大的挑战。胶质母细胞瘤是原发性恶性脑癌中最致命的形式，也是最具侵袭性的形式之一，通常与不良预后和致命结局相关。目前，无机和有机纳米材料的组合已被证明可通过靶向给药系统提高生存率。在本研究中，我们开发了一种使用冷大气等离子体（CAP）和金量子点（AuQDs）治疗脑癌的双重治疗方法。我们的结果表明，CAP和AuQDs通过Fas/TRAIL介导的细胞死亡受体途径在脑癌细胞中诱导双重细胞毒性。此外，CAP和AuQDs联合治疗抑制了脑癌细胞的运动性和球体形成，而这些是癌症侵袭性的公认指标。综上所述，AuQDs的应用可以提高CAP对脑癌细胞的治疗效率，为推进侵袭性胶质母细胞瘤的治疗提供了绝佳机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e889/7072464/ac4030b88819/cancers-12-00457-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e889/7072464/96adc7b4f718/cancers-12-00457-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e889/7072464/efadc70d6b72/cancers-12-00457-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e889/7072464/f0d6aa8307ae/cancers-12-00457-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e889/7072464/e914ec2a8310/cancers-12-00457-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e889/7072464/ac4030b88819/cancers-12-00457-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e889/7072464/96adc7b4f718/cancers-12-00457-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e889/7072464/efadc70d6b72/cancers-12-00457-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e889/7072464/f0d6aa8307ae/cancers-12-00457-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e889/7072464/e914ec2a8310/cancers-12-00457-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e889/7072464/ac4030b88819/cancers-12-00457-g005.jpg

相似文献

1
Cold Atmospheric Plasma and Gold Quantum Dots Exert Dual Cytotoxicity Mediated by the Cell Receptor-Activated Apoptotic Pathway in Glioblastoma Cells.冷大气等离子体和金量子点通过细胞受体激活的凋亡途径对胶质母细胞瘤细胞发挥双重细胞毒性作用。
Cancers (Basel). 2020 Feb 16;12(2):457. doi: 10.3390/cancers12020457.
2
Demonstration of Calreticulin Expression in Hamster Pancreatic Adenocarcinoma with the Use of Fluorescent Gold Quantum Dots.利用荧光金量子点证明钙网蛋白在仓鼠胰腺腺癌中的表达
Anticancer Res. 2016 Mar;36(3):861-7.
3
Cold Atmospheric Plasma Stimulates Clathrin-Dependent Endocytosis to Repair Oxidised Membrane and Enhance Uptake of Nanomaterial in Glioblastoma Multiforme Cells.冷等离体子刺激网格蛋白依赖内吞作用修复氧化细胞膜并增强多形性胶质母细胞瘤细胞对纳米材料的摄取。
Sci Rep. 2020 Apr 24;10(1):6985. doi: 10.1038/s41598-020-63732-y.
4
Nanotechnology Meets Oncology: Nanomaterials in Brain Cancer Research, Diagnosis and Therapy.纳米技术与肿瘤学相遇：纳米材料在脑癌研究、诊断与治疗中的应用
Materials (Basel). 2019 May 15;12(10):1588. doi: 10.3390/ma12101588.
5
Dual-functional supramolecular nanohybrids of quantum dot/biopolymer/chemotherapeutic drug for bioimaging and killing brain cancer cells in vitro.量子点/生物聚合物/化疗药物的双功能超分子纳米杂化物，用于体外生物成像和杀伤脑癌细胞。
Colloids Surf B Biointerfaces. 2019 Dec 1;184:110507. doi: 10.1016/j.colsurfb.2019.110507. Epub 2019 Sep 14.
6
The Antimicrobial Effect of Gold Quantum Dots and Femtosecond Laser Irradiation on the Growth Kinetics of Common Infectious Eye Pathogens: An In Vitro Study.金量子点和飞秒激光照射对常见眼部感染病原体生长动力学的抗菌作用：一项体外研究
Nanomaterials (Basel). 2022 Oct 26;12(21):3757. doi: 10.3390/nano12213757.
7
A new "turn-on" fluorescent sensor based on gold quantum dots and silver nanoparticles for lamotrigine detection in plasma.一种基于金量子点和银纳米粒子的新型“开启”荧光传感器，用于检测血浆中的拉莫三嗪。
Talanta. 2017 Sep 1;172:126-132. doi: 10.1016/j.talanta.2017.05.018. Epub 2017 May 10.
8
Cold Atmospheric Plasma Induces ATP-Dependent Endocytosis of Nanoparticles and Synergistic U373MG Cancer Cell Death.冷等离体子体诱导纳米颗粒依赖于 ATP 的内吞作用，并增强 U373MG 癌细胞死亡。
Sci Rep. 2018 Mar 28;8(1):5298. doi: 10.1038/s41598-018-23262-0.
9
Click gold quantum dots biosynthesis with conjugation of quercetin for adenocarcinoma exertion.通过槲皮素共轭实现用于腺癌治疗的点击金量子点生物合成。
RSC Adv. 2022 Jun 23;12(29):18425-18430. doi: 10.1039/d2ra02529a. eCollection 2022 Jun 22.
10
Cold atmospheric plasma induces apoptosis of melanoma cells via Sestrin2-mediated nitric oxide synthase signaling.冷等离体氛围等离子体通过 Sestrin2 介导的一氧化氮合酶信号诱导黑素瘤细胞凋亡。
J Biophotonics. 2019 Jan;12(1):e201800046. doi: 10.1002/jbio.201800046. Epub 2018 Sep 7.

引用本文的文献

1
The Effect of ZnO Nanoparticles Functionalized with Glutamine and Conjugated with Thiosemicarbazide on Triggering of Apoptosis in the Adenocarcinoma Gastric Cell Line.谷氨酰胺功能化并与氨基硫脲共轭的氧化锌纳米颗粒对人胃腺癌细胞系凋亡的触发作用
Adv Biomed Res. 2024 Aug 26;13:72. doi: 10.4103/abr.abr_412_23. eCollection 2024.
2
Application of quantum dots in brain diseases and their neurotoxic mechanism.量子点在脑部疾病中的应用及其神经毒性机制。
Nanoscale Adv. 2024 Jun 5;6(15):3733-3746. doi: 10.1039/d4na00028e. eCollection 2024 Jul 23.
3
New insights into targeted therapy of glioblastoma using smart nanoparticles.

本文引用的文献

1
Pulsed high-power microwaves do not impair the functions of skin normal and cancer cells : A short-term biological evaluation.脉冲高功率微波不会损害皮肤正常细胞和癌细胞的功能：一项短期生物学评估。
J Adv Res. 2019 Nov 20;22:47-55. doi: 10.1016/j.jare.2019.11.007. eCollection 2020 Mar.
2
The novel circCLK3/miR-320a/FoxM1 axis promotes cervical cancer progression.新型 circCLK3/miR-320a/FoxM1 轴促进宫颈癌进展。
Cell Death Dis. 2019 Dec 12;10(12):950. doi: 10.1038/s41419-019-2183-z.
3
Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro.
利用智能纳米颗粒对胶质母细胞瘤进行靶向治疗的新见解。
Cancer Cell Int. 2024 May 7;24(1):160. doi: 10.1186/s12935-024-03331-3.
4
Unlocking melanoma Suppression: Insights from Plasma-Induced potent miRNAs through PI3K-AKT-ZEB1 axis.解锁黑色素瘤抑制作用：通过PI3K-AKT-ZEB1轴从血浆诱导的强效miRNA中获得的见解。
J Adv Res. 2025 Feb;68:147-161. doi: 10.1016/j.jare.2024.02.022. Epub 2024 Mar 4.
5
Multifunctional Nanocarriers for Alzheimer's Disease: Befriending the Barriers.多功能纳米载体治疗阿尔茨海默病：突破障碍。
Mol Neurobiol. 2024 May;61(5):3042-3089. doi: 10.1007/s12035-023-03730-z. Epub 2023 Nov 15.
6
Applications of Nanomedicine in Brain Tumor Therapy: Nanocarrierbased Drug Delivery Platforms, Challenges, and Perspectives.纳米医学在脑肿瘤治疗中的应用：基于纳米载体的药物递送平台、挑战与展望
Recent Pat Nanotechnol. 2025;19(1):99-119. doi: 10.2174/0118722105244482231017102857.
7
Receptor-Mediated Redox Imbalance: An Emerging Clinical Avenue against Aggressive Cancers.受体介导的氧化还原失衡：对抗侵袭性癌症的新兴临床途径。
Biomolecules. 2022 Dec 15;12(12):1880. doi: 10.3390/biom12121880.
8
The effect of local non-thermal plasma therapy on the cancer-immunity cycle in a melanoma mouse model.局部非热等离子体疗法对黑色素瘤小鼠模型中癌症免疫循环的影响。
Bioeng Transl Med. 2022 Apr 21;7(3):e10314. doi: 10.1002/btm2.10314. eCollection 2022 Sep.
9
Metal-Based Nanostructured Therapeutic Strategies for Glioblastoma Treatment-An Update.用于胶质母细胞瘤治疗的金属基纳米结构治疗策略——最新进展
Biomedicines. 2022 Jul 5;10(7):1598. doi: 10.3390/biomedicines10071598.
10
Biomedical Applications of Quantum Dots: Overview, Challenges, and Clinical Potential.量子点在生物医学中的应用：概述、挑战和临床潜力。
Int J Nanomedicine. 2022 May 2;17:1951-1970. doi: 10.2147/IJN.S357980. eCollection 2022.
金量子点通过下调β-catenin 体外抑制神经胶质瘤干细胞的致瘤性。
Int J Nanomedicine. 2019 Feb 13;14:1131-1148. doi: 10.2147/IJN.S195333. eCollection 2019.
4
Plasma and Nanomaterials: Fabrication and Biomedical Applications.等离子体与纳米材料：制备与生物医学应用
Nanomaterials (Basel). 2019 Jan 14;9(1):98. doi: 10.3390/nano9010098.
5
Approaches to physical stimulation of metallic nanoparticles for glioblastoma treatment.金属纳米颗粒物理刺激方法用于治疗胶质母细胞瘤。
Adv Drug Deliv Rev. 2019 Jan 1;138:344-357. doi: 10.1016/j.addr.2018.10.013. Epub 2018 Nov 7.
6
Cold Atmospheric Plasma Induces ATP-Dependent Endocytosis of Nanoparticles and Synergistic U373MG Cancer Cell Death.冷等离体子体诱导纳米颗粒依赖于 ATP 的内吞作用，并增强 U373MG 癌细胞死亡。
Sci Rep. 2018 Mar 28;8(1):5298. doi: 10.1038/s41598-018-23262-0.
7
Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment.具有双重靶向和 ROS 响应的可追踪纳米颗粒，用于基于 RNAi 的颅内神经胶质瘤免疫化疗治疗。
Adv Mater. 2018 May;30(18):e1705054. doi: 10.1002/adma.201705054. Epub 2018 Mar 25.
8
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.细胞死亡的分子机制：细胞死亡命名委员会 2018 年的建议。
Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23.
9
Selective Killing of Melanoma Cells With Non-Thermal Atmospheric Pressure Plasma and p-FAK Antibody Conjugated Gold Nanoparticles.非热大气压等离子体与 p-FAK 抗体偶联金纳米颗粒选择性杀伤黑素瘤细胞。
Int J Med Sci. 2017 Sep 4;14(11):1101-1109. doi: 10.7150/ijms.20104. eCollection 2017.
10
Combination of cold atmospheric plasma and iron nanoparticles in breast cancer: gene expression and apoptosis study.冷大气等离子体与铁纳米颗粒联合应用于乳腺癌：基因表达与凋亡研究
Onco Targets Ther. 2016 Sep 28;9:5911-5917. doi: 10.2147/OTT.S95644. eCollection 2016.