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导致中国住院儿童呼吸道疾病的五株人冠状病毒NL63的全基因组序列

Complete Genome Sequences of Five Human Coronavirus NL63 Strains Causing Respiratory Illness in Hospitalized Children in China.

作者信息

Zhang Lu, Gan Mian, Zhang Zhaoyong, Li Xin, Liu Wenkuan, Zhu Airu, Sun Jing, Li Fang, Wang Yanqun, Zhang Fuchun, Zhao Jingxian, Zhou Rong, Zhao Jincun

机构信息

Institute of Infectious Disease, Guangzhou Eighth People's Hospital of Guangzhou Medical University, Guangzhou, China.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

出版信息

Microbiol Resour Announc. 2020 Feb 20;9(8):e01597-19. doi: 10.1128/MRA.01597-19.

DOI:10.1128/MRA.01597-19
PMID:32079638
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7033275/
Abstract

We report the complete genome sequences of five human coronavirus NL63 (HCoV-NL63) strains obtained using next-generation sequencing. The five HCoV-NL63 strains were obtained from hospitalized children with severe acute respiratory infection detected in Guangdong, China. This study provides several complete genomes of HCoV-NL63 and improves our understanding of HCoV-NL63 evolution in China.

摘要

我们报告了通过下一代测序获得的五株人冠状病毒NL63（HCoV-NL63）的全基因组序列。这五株HCoV-NL63毒株取自中国广东检测出的患有严重急性呼吸道感染的住院儿童。本研究提供了多株HCoV-NL63的完整基因组，增进了我们对HCoV-NL63在中国进化情况的了解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a92b/7033275/760c12223514/MRA.01597-19-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a92b/7033275/760c12223514/MRA.01597-19-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a92b/7033275/760c12223514/MRA.01597-19-f0001.jpg

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本文引用的文献

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MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization.MAFFT 在线服务：多序列比对、交互式序列选择和可视化。
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Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry.人冠状病毒NL63利用严重急性呼吸综合征冠状病毒受体进入细胞。
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