Kaiser Laurent, Regamey Nicolas, Roiha Hanna, Deffernez Christelle, Frey Urs
Central Laboratory of Virology, Division of Infectious Diseases, University Hospitals of Geneva, Geneva, Switzerland.
Pediatr Infect Dis J. 2005 Nov;24(11):1015-7. doi: 10.1097/01.inf.0000183773.80217.12.
Coronavirus NL63 has been identified as a new member of the coronavirus genus, but its role as a cause of respiratory disease needs to be established. We studied the first episode of lower respiratory tract symptoms in a cohort of healthy neonates. NL63 was identified in 6 (7%) of 82 cases and was as frequent as other coronaviruses (9%). NL63 was recovered at the onset of symptoms and was cleared within 3 weeks in half of the cases. Our data suggests that coronavirus NL63 causes lower respiratory tract symptoms and is acquired in early life.
冠状病毒NL63已被确定为冠状病毒属的一个新成员，但其作为呼吸道疾病病因的作用尚需确定。我们对一组健康新生儿首次出现的下呼吸道症状进行了研究。在82例病例中有6例（7%）检测出NL63，其出现频率与其他冠状病毒相同（9%）。NL63在症状出现时被检测到，半数病例在3周内清除。我们的数据表明，冠状病毒NL63可引起下呼吸道症状，且在生命早期感染。
