Levi M I
Zh Mikrobiol Epidemiol Immunobiol. 1977(1):41-8.
The concentration of the reactive centres of the antibodies in the preparation under study can be determined with the aid of an antibody erythrocytic diagnostic agent. A mathematical substantiation of the suggested method and definite examples of its use are presented. The sensitivity of the serological method of determination of the concentration of the reactive centres of the antibodies largely depended on the valency of the antibody erythrocytes and the heterogeneity of the antibodies. This method permits to determine the sum of the reactive antibody centres equivalent to the definite concentration of the molecules of the standard antigen whose valency remains unknown.
所研究制剂中抗体反应中心的浓度可借助抗体红细胞诊断剂来确定。文中给出了所建议方法的数学依据及其具体应用实例。抗体反应中心浓度测定的血清学方法的灵敏度在很大程度上取决于抗体红细胞的价态和抗体的异质性。该方法能够确定与价态未知的标准抗原分子的特定浓度相当的反应性抗体中心的总和。
