Hassanpour Mehdi, Hajihassani Fateme, Hiradfar Amirataollah, Aghamohammadzadeh Nasser, Rahbarghazi Reza, Safaie Nasser, Nouri Mohammad, Panahi Yunes
1Department of Clinical Biochemistry and Laboratory Medicine, Tabriz University of Medical Sciences, 5166614756, Imam Reza St., Golgasht St, Tabriz, Iran.
2Stem Cell And Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
J Inflamm (Lond). 2020 Feb 11;17:6. doi: 10.1186/s12950-020-0237-8. eCollection 2020.
The occurrence of neurodegenerative disease is increasingly raised. From physiopathological aspect, the emergence of auto-reactive antibodies against the nervous system antigens contributes to de-myelination in Multiple sclerosis (MS). These features cause the nervous system dysfunction. The follow-up of molecular alterations could give us a real-state vision about intracellular status during pathological circumstances. In this review, we focus on the autophagic response during MS progression and further understand the relationship between autophagy and MS and its modulatory effect on the MS evolution. The authors reviewed studies published on the autophagy status in neurodegenerative disease and on the autophagy modulation in MS prognosis, diagnosis, and possible therapies. The inevitable role of autophagy was shown in the early-stage progression of MS. Due to critical role of autophagy in different stage of cell activity in nervous system, the distinct role of autophagy should not be neglected in the development, pathogenesis, and treatment of MS.
神经退行性疾病的发生率日益升高。从生理病理学角度来看，针对神经系统抗原的自身反应性抗体的出现导致了多发性硬化症（MS）中的脱髓鞘。这些特征会引起神经系统功能障碍。对分子改变的追踪可以让我们了解病理情况下细胞内状态的真实情况。在本综述中，我们聚焦于MS进展过程中的自噬反应，并进一步了解自噬与MS之间的关系及其对MS进展的调节作用。作者回顾了关于神经退行性疾病中自噬状态以及MS预后、诊断和可能治疗中自噬调节的已发表研究。自噬在MS的早期进展中显示出不可避免的作用。由于自噬在神经系统细胞活动的不同阶段起着关键作用，因此在MS的发生、发病机制和治疗中，自噬的独特作用不应被忽视。
