Zand Vahid, Baradaranfar Mohammadhossein, Vaziribozorg Sedighe, Mandegari Mohammad, Mansourimanesh Mahzad, Saeidieslami Nasir
Department of Otolaryngology - Head and Neck Surgery , Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Anesthesiology , Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Iran J Otorhinolaryngol. 2020 Jan;32(108):35-41. doi: 10.22038/ijorl.2019.31926.2050.
The present study was conducted to investigate the association between the serum vitamin D levels and severity of disease in chronic rhino sinusitis (CRS) patients.
This prospective cross-sectional study was conducted on a total of 93 patients suffering from chronic rhino sinusitis with nasal polyposis (CRS w NP). Serum level of 25-hydroxyvitamin D was detected using a simple blood test. A22-item questionnaire, namely the sinonasal outcome test-22 (SNOT-22), was used to assess the subjective disease severity and patients' quality of life. In addition, the radiographic signs of the disease severity were evaluated using the Lund-Mackay Scale (LMS).
The mean age and serum vitamin D level of the patients were measured at 37.7±13.6 years and 24.6±16.9 ng/ml, respectively. Moreover, the mean of LMS and SNOT-22 scores were calculated at 14.2±11.2 and 40.8±17.6, respectively. There was a negative correlation between the SNOT-22 and serum levels of vitamin D (P=0.034). Similarly, LMS and serum vitamin D levels were correlated negatively (P=0.027). Furthermore, the results revealed a direct relationship between LMS and SNOT-22 (P<0.0001).
According to the obtained results, there was a significant relationship between the serum vitamin D levels and severity of disease in patients with CRS w NP. Therefore, serum vitamin D levels could be added to the routine workup of the patients suffering from CRS w NP.
本研究旨在调查慢性鼻-鼻窦炎（CRS）患者血清维生素D水平与疾病严重程度之间的关联。
本前瞻性横断面研究共纳入93例患有鼻息肉的慢性鼻-鼻窦炎（CRS伴鼻息肉，CRS w NP）患者。通过简单的血液检测来测定血清25-羟基维生素D水平。使用一份包含22个条目的问卷，即鼻窦结局测试-22（SNOT-22），来评估主观疾病严重程度和患者的生活质量。此外，使用Lund-Mackay量表（LMS）评估疾病严重程度的影像学征象。
患者的平均年龄和血清维生素D水平分别测得为37.7±13.6岁和24.6±16.9 ng/ml。此外，LMS和SNOT-22评分的平均值分别计算为14.2±11.2和40.8±17.6。SNOT-22与维生素D血清水平之间存在负相关（P = 0.034）。同样，LMS与血清维生素D水平呈负相关（P = 0.027）。此外，结果显示LMS与SNOT-22之间存在直接关系（P < 0.0001）。
根据所得结果，CRS w NP患者的血清维生素D水平与疾病严重程度之间存在显著关系。因此，血清维生素D水平可纳入CRS w NP患者的常规检查中。
