School of Pharmacy, Nanchang University, Nanchang 330006, China.
Pharmacy Department, Jiangxi Provincial Children's Hospital, Nanchang 330000, China.
Biomed Res Int. 2019 Oct 31;2019:8912961. doi: 10.1155/2019/8912961. eCollection 2019.
Curcumin has been shown to have anticancer effects in a variety of tumors. However, there are fewer studies on the role of curcumin in endometrial carcinoma (EC). The purpose of this experiment was to examine the inhibitory effect of curcumin on endometrial carcinoma cells and ERK/c-Jun signaling pathway. We first predicted the mechanism of action of curcumin on endometrial carcinoma by network pharmacology. Then, we found that curcumin can decrease the cell viability of Ishikawa cells, inhibit the migration of cancer cells, induce apoptosis, and cause cell cycle arrest in the S phase. For molecular mechanism, curcumin reduced the mRNA expression levels of ERK2 and JUN genes and inhibited the phosphorylation of ERK and c-Jun. This suggests that curcumin inhibits the proliferation of endometrial carcinoma cells by downregulating ERK/c-Jun signaling pathway activity.
姜黄素已被证明在多种肿瘤中有抗癌作用。然而，关于姜黄素在子宫内膜癌（EC）中的作用的研究较少。本实验旨在研究姜黄素对子宫内膜癌细胞和 ERK/c-Jun 信号通路的抑制作用。我们首先通过网络药理学预测姜黄素对子宫内膜癌的作用机制。然后，我们发现姜黄素可以降低 Ishikawa 细胞的细胞活力，抑制癌细胞的迁移，诱导细胞凋亡，并使细胞周期在 S 期停滞。在分子机制上，姜黄素降低了 ERK2 和 JUN 基因的 mRNA 表达水平，并抑制了 ERK 和 c-Jun 的磷酸化。这表明姜黄素通过下调 ERK/c-Jun 信号通路活性来抑制子宫内膜癌细胞的增殖。
