Department of Gynecology and Obstetrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Zunyi Medical University Affiliated Hospital of Obstetrics and Gynecology, Zunyi 563003, China.
Biomed Res Int. 2020 Jan 29;2020:6842963. doi: 10.1155/2020/6842963. eCollection 2020.
Cervical cancer is the most common gynecological tumor worldwide. Persistent infection of high-risk HPV-induced smouldering inflammation is considered to be an important risk factor for cervical cancer. The tumor microenvironment (TME) plays an important role in the progress of the tumor occurrence, development, and prognosis of cervical cancer. Macrophages are the main contributor to the TME, which is called tumor-associated macrophages (TAMs). During the inflammatory response, the phenotype and function of TAMs are constantly changing, which are involved in different regulatory networks. The phenotype of TAMs is related to the metabolism and secretory factors release, which facilitate the angiogenesis and lymphatic duct formation during cervical cancer metastasis, thus affecting the prognosis of cervical cancer. This review intends to discuss the recent research progress on the relationship between TAMs and cervical cancer, which is helpful to elucidate the mechanism of TAMs in cervical cancer.
宫颈癌是全球最常见的妇科肿瘤。持续性高危型 HPV 感染引起的潜伏性炎症被认为是宫颈癌的重要危险因素。肿瘤微环境（TME）在宫颈癌的发生、发展和预后中起着重要作用。巨噬细胞是 TME 的主要贡献者，称为肿瘤相关巨噬细胞（TAMs）。在炎症反应过程中，TAMs 的表型和功能不断变化，参与不同的调控网络。TAMs 的表型与代谢和分泌因子的释放有关，这有助于促进宫颈癌转移过程中的血管生成和淋巴管形成，从而影响宫颈癌的预后。本文旨在讨论 TAMs 与宫颈癌之间的关系的最新研究进展，这有助于阐明 TAMs 在宫颈癌中的作用机制。
