State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Laboratory Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, China.
The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Biosci Rep. 2021 May 28;41(5). doi: 10.1042/BSR20203145.
Tumor microenvironment (TME) plays a particularly important role in the progression, invasion and metastasis of cervical carcinoma (CC). Tumor-associated macrophages (TAMs) are significant components of the tumor microenvironment in CC. However, the results of studies on the correlation between TAMs and progression in CC are still controversial. This research aimed to investigate the relationship between TAMs infiltration and progression in CC. A total of 100 patients with CC were included in the study. The correlation between TAMs and clinicopathologic features was studied. Besides, a systematic literature search was conducted from legitimate electronic databases to specifically evaluate the role of TAMs in TME of cervical carcinoma. In the meta-analysis, high stromal CD68+ TAMs density was relevant to lymph node metastasis (WMD = 11.89, 95% CI: 5.30-18.47). At the same time, CD163+ M2 TAM density was associated with lymph node metastasis (OR = 2.42, 95% CI: 1.09-5.37; WMD = 39.37, 95% CI: 28.25-50.49) and FIGO stage (WMD = -33.60, 95% CI: -45.04 to -22.16). This was further confirmed in the experimental study of 100 tissues of cervical cancer. It supported a critical role of TAMs as a prospective predictor of cervical cancer. In conclusion, CD68+ TAM and CD163+ M2 TAM infiltration in CC were associated with tumor progression. And CD163+ M2 TAM infiltration was associated with more advanced FIGO stage and lymph node metastasis in CC.
肿瘤微环境（TME）在宫颈癌（CC）的进展、侵袭和转移中起着特别重要的作用。肿瘤相关巨噬细胞（TAMs）是 CC 肿瘤微环境的重要组成部分。然而，关于 TAMs 与 CC 进展之间相关性的研究结果仍存在争议。本研究旨在探讨 TAMs 浸润与 CC 进展之间的关系。共纳入 100 例 CC 患者，研究 TAMs 与临床病理特征的相关性。此外，还从合法的电子数据库中进行了系统的文献检索，专门评估 TAMs 在宫颈癌肿瘤微环境中的作用。在荟萃分析中，高基质 CD68+TAMs 密度与淋巴结转移相关（WMD=11.89，95%CI：5.30-18.47）。同时，CD163+M2 TAM 密度与淋巴结转移（OR=2.42，95%CI：1.09-5.37；WMD=39.37，95%CI：28.25-50.49）和 FIGO 分期（WMD=-33.60，95%CI：-45.04 至-22.16）相关。这在对 100 例宫颈癌组织的实验研究中得到了进一步证实。它支持 TAMs 作为宫颈癌有前途的预测因子的关键作用。总之，CC 中 CD68+TAM 和 CD163+M2 TAM 浸润与肿瘤进展有关。并且 CD163+M2 TAM 浸润与 CC 中更晚期的 FIGO 分期和淋巴结转移相关。
