Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Drug Metab Rev. 2020 Feb;52(1):205-224. doi: 10.1080/03602532.2020.1726943. Epub 2020 Feb 21.
Nowadays, magnetic nanoparticles (MNPs) have been rapidly investigated and attracted worldwide attention due to their great potential as mediators of heat for treating hyperthermia and their possibility to deliver drugs at specific locations, which can thereby limit systematic effects. Cancer therapy via MNPs proposes novel properties rather than normal methods such as almost zero side effects and a high-efficiency rate of effectiveness. The key aim of targeted drug delivery is to reduce side effects of the main cancer treatment that other usual chemotherapies will attend to the body, and thus controlling the effectiveness of the drug on a specific location that tumoral tissue exist. Herein, the high potential of MNPs has been studied, and different examples of their effectiveness on drug delivery and hypothermia therapy have been provided.
如今，由于磁性纳米粒子 (MNPs) 在治疗高温和将药物递送到特定位置方面具有很大的潜力，因此作为热疗的介质，它们受到了全球的关注。MNPs 用于癌症治疗具有许多新的特性，而不是正常的方法，如几乎零副作用和高效率的疗效。靶向药物输送的关键目标是减少主要癌症治疗的副作用，而其他常规化疗会对身体产生副作用，从而控制药物在存在肿瘤组织的特定位置的有效性。本文研究了 MNPs 的高潜力，并提供了其在药物输送和低温治疗方面的有效性的不同例子。
