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用于在胶质母细胞瘤细胞中控制替莫唑胺递送的磁性和pH敏感纳米复合微球。

Magnetic and pH sensitive nanocomposite microspheres for controlled temozolomide delivery in glioblastoma cells.

作者信息

Ahmadi Meysam, Ashoub Muhammad Hossein, Heydaryan Kamran, Abolghasemi Sanaz, Dawi Elmuez A, Khajouei Ghazal, Amiri Mahnaz

机构信息

Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Science, Kerman, Iran.

Department of Hematology and Medical Laboratory Sciences, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran.

出版信息

Sci Rep. 2024 Dec 2;14(1):29897. doi: 10.1038/s41598-024-80596-8.

DOI:10.1038/s41598-024-80596-8
PMID:39622938
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11612508/
Abstract

Controlled drug delivery systems have been intensively researched for cancer treatment to increase precision targeting and therapeutic efficacy. In this context, novel magnetic-/pH-sensitive graphene oxide/chitosan/iron oxide magnetic nanocomposite microspheres were synthesized. FeO (IO) nanoparticles (NPs) were synthesized via the green synthesis method in the presence of Salvia officinalis extract. The graphene oxide (GO) NPs were prepared using the Staudenmaier method, and synthesized materials were characterized. Chitosan (CS) was used to prepare microspheres. GO/CS/IO microspheres were investigated as prospective vehicles for controlled temozolomide delivery in the presence and absence of an external magnetic field. The release percentage of temozolomide molecules in the presence of 100 Hz reached a maximum in 90 min. This is approximately twice the amount of drug release in the absence of a magnetic field and more than that in the presence of a 50 Hz magnetic field. Also, the highest degree of swelling was observed at a pH of 4.5, higher than at a pH of 7.4. Also, the MTT assay results indicated the cytotoxicity of the synthesized microspheres for glioblastoma cells; notably, a significant difference was observed between the groups exposed to the magnetic field and those not, with exposure to the magnetic field further reducing survival. These results indicated that the magnetic microspheres potentially apply to controlled drug delivery systems.

摘要

为提高精准靶向性和治疗效果，人们对用于癌症治疗的可控药物递送系统进行了深入研究。在此背景下，合成了新型磁性/pH敏感的氧化石墨烯/壳聚糖/氧化铁磁性纳米复合微球。在鼠尾草提取物存在的情况下，通过绿色合成法合成了FeO（IO）纳米颗粒（NPs）。采用施陶登迈尔法制备氧化石墨烯（GO）NPs，并对合成材料进行了表征。使用壳聚糖（CS）制备微球。研究了GO/CS/IO微球在有和没有外部磁场的情况下作为替莫唑胺可控递送的潜在载体。在100Hz存在的情况下，替莫唑胺分子的释放百分比在90分钟内达到最大值。这大约是在没有磁场情况下药物释放量的两倍，且超过在50Hz磁场存在情况下的释放量。此外，在pH为4.5时观察到最高的溶胀度，高于pH为7.4时的溶胀度。此外，MTT分析结果表明合成的微球对胶质母细胞瘤细胞具有细胞毒性；值得注意的是，在暴露于磁场的组和未暴露于磁场的组之间观察到显著差异，暴露于磁场会进一步降低细胞存活率。这些结果表明磁性微球可能适用于可控药物递送系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/095f576b723a/41598_2024_80596_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/1da1dceafcbb/41598_2024_80596_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/5e2fd9f73232/41598_2024_80596_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/86b6b6c1b6e4/41598_2024_80596_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/3f81331cad20/41598_2024_80596_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/0580000ba6ec/41598_2024_80596_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/b778cb25785f/41598_2024_80596_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/7cbf52e98041/41598_2024_80596_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/1d8c1b54eb09/41598_2024_80596_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/ebaba0d27128/41598_2024_80596_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/490d8394c5b6/41598_2024_80596_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/095f576b723a/41598_2024_80596_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/1da1dceafcbb/41598_2024_80596_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/5e2fd9f73232/41598_2024_80596_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/86b6b6c1b6e4/41598_2024_80596_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/3f81331cad20/41598_2024_80596_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/0580000ba6ec/41598_2024_80596_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/b778cb25785f/41598_2024_80596_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/7cbf52e98041/41598_2024_80596_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/1d8c1b54eb09/41598_2024_80596_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/ebaba0d27128/41598_2024_80596_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/490d8394c5b6/41598_2024_80596_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11612508/095f576b723a/41598_2024_80596_Fig11_HTML.jpg

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