缅甸医院耐多药鲍曼不动杆菌分离株的分子流行病学研究。
Molecular epidemiology of multidrug-resistant Acinetobacter baumannii isolates from hospitals in Myanmar.
机构信息
Department of Microbiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Department of Microbiome Research, Juntendo University Graduate School of Medicine, Tokyo, Japan.
出版信息
J Glob Antimicrob Resist. 2020 Sep;22:122-125. doi: 10.1016/j.jgar.2020.02.011. Epub 2020 Feb 19.
OBJECTIVE
The aim of this study was to clarify the genetic and epidemiological properties of multidrug-resistant Acinetobacter baumannii in medical settings in Myanmar.
METHODS
A total of 45 A. baumannii clinical isolates were obtained in medical settings in Myanmar. The whole genomes were sequenced by a next generation sequencer, and the phylogenetic tree was constructed from single nucleotide polymorphism concatemers. Multilocus sequence types were deduced and drug resistance genes were identified.
RESULTS
Thirty-eight MDR Acinetobacter baumannii isolates were obtained from seven hospitals in Myanmar. The majority of MDR A. baumannii isolates belonged to ST2. Of the 38 isolates, 5 harbored bla, and 28 did armA or armA2 CONCLUSIONS: A. baumannii ST2 producing 16S rRNA methylase ArmA has been spreading in medical settings in Myanmar.
目的
本研究旨在阐明缅甸医疗机构中多重耐药鲍曼不动杆菌的遗传和流行病学特征。
方法
从缅甸医疗机构中获得了 45 株鲍曼不动杆菌临床分离株。通过下一代测序仪对全基因组进行测序，并从单核苷酸多态性串联构建系统发育树。推断出多位点序列类型并鉴定耐药基因。
结果
从缅甸的七家医院获得了 38 株 MDR 鲍曼不动杆菌分离株。大多数 MDR 鲍曼不动杆菌分离株属于 ST2。在 38 株分离株中，5 株携带 bla，28 株携带 armA 或 armA2。
结论
在缅甸的医疗机构中，产生 16S rRNA 甲基化酶 ArmA 的鲍曼不动杆菌 ST2 正在传播。
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