Zou Tiande, Wei Wenzhuo, Cao Shanchuan, Zhang Hongfu, Liu Jingbo
School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China.
Jiangxi Province Key Laboratory of Animal Nutrition, Engineering Research Center of Feed Development, Jiangxi Agricultural University, Nanchang 330045, China.
Animals (Basel). 2020 Feb 18;10(2):319. doi: 10.3390/ani10020319.
This study aimed to investigate the effects of maternal lipopolysaccharide (LPS) challenge and dietary fat sources on colostrum quality and inflammatory response in sows. Sixty Landrace × Yorkshire sows were randomly assigned to three dietary treatments supplemented with 3% soybean oil (SO), 3% coconut oil (CO) or 3% fish oil (FO), respectively, from Day 90 of gestation until parturition. On Day 112 of gestation, half the sows from each dietary treatment were challenged with LPS (10 μg/kg BW) or saline. The results showed that maternal LPS challenge decreased colostrum yield and dry matter content. A similar pattern of changes was observed for body weight gain and colostrum intake in piglets from LPS-challenged sows. Maternal LPS challenge increased the levels of tumor necrosis factor α (), interleukin 1β () and in colostum, and the mRNA abundance of , and and the phosphorylation level of in mammary glands. However, the responses of these variables to LPS treatment were lower in sows fed a FO diet. In conclusion, maternal immune challenge reduced the growth performance of piglets by decreasing colostrum yield and intake by piglets, and dietary supplementation with FO in sows attenuates the LPS-induced inflammatory response in mammary glands.
本研究旨在探讨母体脂多糖（LPS）刺激和日粮脂肪来源对母猪初乳质量和炎症反应的影响。60头长白×约克夏母猪从妊娠第90天至分娩分别随机分为三组，日粮分别添加3%大豆油（SO）、3%椰子油（CO）或3%鱼油（FO）。在妊娠第112天，每组日粮处理的一半母猪接受LPS（10μg/kg体重）或生理盐水刺激。结果表明，母体LPS刺激降低了初乳产量和干物质含量。在LPS刺激的母猪所产仔猪的体重增加和初乳摄入量方面也观察到了类似的变化模式。母体LPS刺激增加了初乳中肿瘤坏死因子α（TNF-α）、白细胞介素1β（IL-1β）和IL-6的水平，以及乳腺中TNF-α、IL-1β和IL-6的mRNA丰度和NF-κB的磷酸化水平。然而，在饲喂FO日粮的母猪中，这些变量对LPS处理的反应较低。总之，母体免疫刺激通过降低仔猪初乳产量和摄入量降低了仔猪的生长性能，母猪日粮中添加FO可减轻LPS诱导的乳腺炎症反应。
