School of Biosciences and Centre for Interdisciplinary Studies of Reproduction, University of Kent, Giles Lane, Canterbury CT2 7NJ, UK.
Genes (Basel). 2020 Feb 18;11(2):210. doi: 10.3390/genes11020210.
Spermatogenesis requires radical restructuring of germline chromatin at multiple stages, involving co-ordinated waves of DNA methylation and demethylation, histone modification, replacement and removal occurring before, during and after meiosis. This Special Issue has drawn together papers addressing many aspects of chromatin organization and dynamics in the male germ line, in humans and in model organisms. Two major themes emerge from these studies: the first is the functional significance of nuclear organisation in the developing germline; the second is the interplay between sperm chromatin structure and susceptibility to DNA damage and mutation. The consequences of these aspects for fertility, both in humans and other animals, is a major health and social welfare issue and this is reflected in these nine exciting manuscripts.
精子发生需要在多个阶段对生殖系染色质进行彻底的结构重排，涉及 DNA 甲基化和去甲基化、组蛋白修饰的协调波、在减数分裂前后和期间发生的替代和去除。本特刊汇集了探讨男性生殖系染色质组织和动态的许多方面的论文，涉及人类和模式生物。这些研究中有两个主要主题：第一个是核组织在发育中的生殖系中的功能意义；第二个是精子染色质结构与 DNA 损伤和突变易感性之间的相互作用。这些方面对人类和其他动物的生育能力的影响是一个主要的健康和社会福利问题，这在这九篇令人兴奋的手稿中得到了反映。
