非编码 RNA 在 CD8+T 细胞生物学中的作用。
Non-coding RNAs in CD8 T cell biology.
机构信息
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20814, United States.
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, 01003, United States.
出版信息
Mol Immunol. 2020 Apr;120:67-73. doi: 10.1016/j.molimm.2020.01.023. Epub 2020 Feb 18.
Abstract
CD8 T cells are among the most vigorous soldiers of the immune system that fight viral infections and cancer. CD8 T cell development, maintenance, activation and differentiation are under the tight control of multiple transcriptional and post-transcriptional networks. Over the last two decades it has become clear that non-coding RNAs (ncRNAs), which consist of microRNAs (miRNAs) and long ncRNAs (lncRNAs), have emerged as global biological regulators. While our understanding of the function of specific miRNAs has increased since the discovery of RNA interference, it is still very limited, and the field of lncRNAs is just starting to blossom. Here we will summarize our knowledge on the role of ncRNAs in CD8 T cell biology, including differentiation into memory and exhausted cells.
摘要
CD8 T 细胞是免疫系统中最具活力的战士之一，能够对抗病毒感染和癌症。CD8 T 细胞的发育、维持、激活和分化受到多个转录和转录后网络的严格控制。在过去的二十年中，人们已经清楚地认识到非编码 RNA（ncRNA），包括 microRNAs（miRNAs）和长非编码 RNA（lncRNAs），已经成为全球性的生物调节剂。虽然自 RNA 干扰的发现以来，我们对特定 miRNAs 功能的理解有所增加，但仍然非常有限，lncRNAs 领域才刚刚开始兴起。在这里，我们将总结 ncRNA 在 CD8 T 细胞生物学中的作用的知识，包括分化为记忆细胞和耗竭细胞。
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