[舌下免疫疗法对变应性鼻炎患者的疗效]
[Effect of sublingual immunotherapy on patients with allergic rhinitis].
作者信息
Yang J, Jiang H, Xiang Y L, Wu Y
机构信息
Department of Otolaryngology Head and Neck Surgery，Yongchuan Hospital Affiliated to Chongqing Medical University，Chongqing，402160，China.
出版信息
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jan;34(1):53-56. doi: 10.13201/j.issn.1001-1781.2020.01.013.
Study the efficacy of sublingual immunotherapy （SLIT） for monosensitized and polysensitized allergic rhinitis patients of different severity. According to the results of intradermal experiments, 186 patients with AR who were treated with standardized dust mites SLIT for 2 years. These patients have been divided into mild monosensitized group and mild polysensitized group, moderate monosensitized group and moderate polysensitized group, severe monosensitized group and severe polysensitized group. Statistics and analysis of total nasal symptom score （TNSS）, total medication score （TMS） , visual analog scale （VAS） about before and after SLIT treatment. Before SLIT treatment and after 2 years, the TNSS: Mild monosensitized group （5. 58±1. 68）（0. 58±0. 75）, mild polysensitized group（5. 34±1. 49）（0. 93±0. 75）;moderate monosensitized group （4. 68±1. 55）（0. 32±0. 63）, moderate polysensitized group（6. 26±1. 46）（0. 61±0. 67）,which have showed a statistically significant difference（<0.05）,between the two groups have no significant difference （>0.05）. Severe monosensitized group（6. 26±0. 73）（1. 16±1. 13）, severe polysensitized group（6. 49±1. 04）（1. 89±1. 07）, which have showed a statistically significant difference（<0.05）, between the two groups have a statistically significant difference（<0.05）. The VAS:Mild monosensitized group （6. 09±1. 23）（1. 52±1. 25）, mild polysensitized group（6. 21±0. 90）（1. 97±1. 18）,moderate monosensitized group（6. 12±0. 53）（1. 16±1. 03）, moderate polysensitized group（6. 65±1. 08）（1. 65±0. 98）,which have showed a statistically significant difference（<0.05）,between the two groups have no significant difference （>0.05）. Severe monosensitized group（6. 26±0. 73）（1. 16±1. 13）, severe polysensitized group（6. 49±1. 04）（1. 89±1. 07）, which have showed a statistically significant difference（<0.05）, between the two groups have a statistically significant difference（<0.05）. The TMS:These have showed a statistically significant difference（<0.05）with same group,between all groups have no significant difference （>0.05）. Dust mites under the SLIT are effective for monosensitized and polysensitized allergic patients. For patients with severe polysensitized , it is necessary to extend the treatment time （>2 years）.
研究舌下免疫疗法（SLIT）对不同严重程度的单敏和多敏性过敏性鼻炎患者的疗效。根据皮内试验结果，186例接受标准化尘螨SLIT治疗2年的变应性鼻炎患者。这些患者被分为轻度单敏组和轻度多敏组、中度单敏组和中度多敏组、重度单敏组和重度多敏组。对SLIT治疗前后的总鼻症状评分（TNSS）、总用药评分（TMS）、视觉模拟量表（VAS）进行统计分析。SLIT治疗前及2年后，TNSS：轻度单敏组（5.58±1.68）（0.58±0.75），轻度多敏组（5.34±1.49）（0.93±0.75）；中度单敏组（4.68±1.55）（0.32±0.63），中度多敏组（6.26±1.46）（0.61±0.67），两组间差异有统计学意义（<0.05），组内差异无统计学意义（>0.05）。重度单敏组（6.26±0.73）（1.16±1.13），重度多敏组（6.49±1.04）（1.89±1.07），两组间差异有统计学意义（<0.05），组内差异有统计学意义（<0.05）。VAS：轻度单敏组（6.09±1.23）（1.52±1.25），轻度多敏组（6.21±0.90）（1.97±1.18），中度单敏组（6.12±0.53）（1.16±1.03），中度多敏组（6.65±1.08）（1.65±0.98），两组间差异有统计学意义（<0.05），组内差异无统计学意义（>0.05）。重度单敏组（6.26±0.73）（1.16±1.13），重度多敏组（6.49±1.04）（1.89±1.07），两组间差异有统计学意义（<0.05），组内差异有统计学意义（<0.05）。TMS：同组间差异有统计学意义（<0.05），各组间差异无统计学意义（>0.05）。SLIT下的尘螨对单敏和多敏性过敏患者有效。对于重度多敏患者，有必要延长治疗时间（>2年）。
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