Post-graduate Program of Health Sciences, State University of Montes Claros, Montes Claros, Minas Gerais, Brazil.
Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
Med Hypotheses. 2020 Jun;139:109614. doi: 10.1016/j.mehy.2020.109614. Epub 2020 Feb 6.
Diabetes is a metabolic condition associated with hyperglycemia manifested by the elevation of blood glucose levels occurring when the pancreas decreases or stops the production of insulin, in case of insulin resistance or both. The current literature supports that insulin resistance may be responsible for the memory decline associated with diabetes. Glucose transporters (GLUTs) are a family of proteins involved in glucose transport across biological membranes. GLUT-1 and GLUT-3 are involved in glucose delivery to the brain. Evidence suggests that both transporters are downregulated in chronic peripheral hyperglycemia. Here we show the mechanisms of glucose transport and its influence on cognitive function, including a hypothesis of how peripheral hyperglycemia related genes network interactions may lead to glucose transporters downregulation and its possible consequences.
糖尿病是一种与高血糖相关的代谢疾病，表现为当胰腺减少或停止胰岛素的产生时，血液中的葡萄糖水平升高，这种情况可能是由于胰岛素抵抗或两者兼有。目前的文献支持胰岛素抵抗可能是导致与糖尿病相关的记忆衰退的原因。葡萄糖转运蛋白（GLUTs）是一组参与葡萄糖跨生物膜转运的蛋白质。GLUT-1 和 GLUT-3 参与葡萄糖向大脑的输送。有证据表明，这两种转运蛋白在慢性外周高血糖症中都下调。在这里，我们展示了葡萄糖转运的机制及其对认知功能的影响，包括一个关于外周高血糖相关基因网络相互作用如何导致葡萄糖转运蛋白下调及其可能后果的假说。
