Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
Smart Aging Research Center, Tohoku University, Sendai 980-8575, Japan.
Nutrients. 2023 Feb 7;15(4):842. doi: 10.3390/nu15040842.
The association of diet and nutrients with dementia risk is an interesting research topic. Middle-aged and older Europeans not diagnosed with dementia within two years of baseline were followed up and their data were analysed until 2021. The association between the nutrient quintiles measured by the web-based 24 h dietary and the risk of developing dementia was examined using a Cox proportional hazard model after adjusting for potential confounding factors. Approximately 160,000 subjects and 1200 cases were included in the analysis of each nutrient. A greater risk of dementia was associated with (a) no alcohol intake (compared with moderate to higher intake), (b) higher intake of total sugars and carbohydrates (compared with lower intake), (c) highest or lowest fat intake (compared with moderate intake), (d) quintiles of highest or lowest magnesium intake (compared with the quintile of the second highest intake), and (e) highest protein intake (compared with moderate intake). Overall, the present results are congruent with the importance of a moderate intake of certain nutrients.
饮食和营养素与痴呆风险的相关性是一个有趣的研究课题。本研究随访了未在基线后两年内被诊断为痴呆的中老年欧洲人，并对其数据进行了分析，直至 2021 年。采用 Cox 比例风险模型，在调整潜在混杂因素后，分析了基于网络的 24 小时膳食中测量的营养素五分位数与痴呆发病风险之间的关系。在对每种营养素的分析中，大约有 16 万名受试者和 1200 例病例。与（a）适量至更高摄入相比，（b）与总糖和碳水化合物摄入较高相比，（c）与脂肪摄入较高或较低相比，（d）与镁摄入最高或最低五分位数相比（与第二高五分位数相比），以及（e）与适量摄入相比，更高的蛋白质摄入与痴呆风险呈正相关。总的来说，目前的结果与某些营养素适度摄入的重要性一致。
