Dogan Keziban, Helvacioglu Caglar, Baghaki Sema, Ekin Murat
Department of Obstetrics and Gynecology, University of Health Sciences, Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital, Istanbul, Turkey.
Diabetes Metab Syndr. 2020 Mar-Apr;14(2):137-139. doi: 10.1016/j.dsx.2020.01.008. Epub 2020 Jan 29.
This study showed that there is a positive correlation between serum Visceral Adipose tissue derived Serine Protease Inhibitor (VASPIN) level and polycystic ovary syndrome (PCOS). In previous studies, this relation was attributed to the generalization of higher amount of adipose tissue in patients with PCOS. However, we detected that VASPIN is significantly high in patients with PCOS regardless of BMI. Besides, the metabolic parameters such as fasting insulin, HOMA-IR, triglycerides and LDL-C levels were also increased in lean women with PCOS.
本研究表明，血清内脏脂肪组织衍生丝氨酸蛋白酶抑制剂（VASPIN）水平与多囊卵巢综合征（PCOS）之间存在正相关。在以往的研究中，这种关系归因于PCOS患者体内脂肪组织量增加这一普遍现象。然而，我们发现，无论BMI如何，PCOS患者的VASPIN水平均显著升高。此外，PCOS瘦型女性的代谢参数如空腹胰岛素、HOMA-IR、甘油三酯和低密度脂蛋白胆固醇（LDL-C）水平也有所升高。
