Yasir Md, Senthilkumar Gandhipuram Periyasamy, Jayashree Kuppuswami, Ramesh Babu K, Vadivelan Mehalingam, Palanivel Chinnakali
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Puducherry, India.
Department of Biochemistry, North Eastern Indira Gandhi Regional Institute of Health & Medical Sciences (NEIGRIHMS), Shillong, India.
Arch Physiol Biochem. 2022 Apr;128(2):313-320. doi: 10.1080/13813455.2019.1680698. Epub 2019 Nov 5.
Omentin-1 is a novel adipokine with anti-inflammatory functions. Apelin is associated with hyperinsulinemia and pathological angiogenesis. Chemerin has both pro- and anti-inflammatory actions and implicated in insulin resistance and metabolic syndrome. The aim of this study was to assess serum omentin-1, apelin and chemerin concentrations and to investigate their association with the presence and severity of DR in T2DM patients. Serum omentin-1, apelin and chemerin were measured in 112 patients with DR and 56 patients without DR. Bivariate analysis showed omentin-1 correlated negatively with hsCRP and TyG index; while apelin correlated positively with chemerin. Linear regression data showed that apelin and chemerin were independent predictors of DR severity. ROC curve revealed that omentin-1 was the best discriminant for DR while apelin was the best discriminant for vision threatening retinopathy. Serum omentin-1 concentration correlates negatively, while serum apelin and chemerin concentrations correlate positively with DR presence and severity in T2DM patients.
网膜素-1是一种具有抗炎功能的新型脂肪因子。Apelin与高胰岛素血症和病理性血管生成有关。趋化素具有促炎和抗炎作用，并与胰岛素抵抗和代谢综合征有关。本研究的目的是评估2型糖尿病患者血清网膜素-1、Apelin和趋化素的浓度，并研究它们与糖尿病视网膜病变（DR）的存在及严重程度的关系。对112例患有DR的患者和56例未患DR的患者进行了血清网膜素-1、Apelin和趋化素的检测。双变量分析显示，网膜素-1与高敏C反应蛋白（hsCRP）和TyG指数呈负相关；而Apelin与趋化素呈正相关。线性回归数据显示，Apelin和趋化素是DR严重程度的独立预测因子。ROC曲线显示，网膜素-1是DR的最佳判别指标，而Apelin是威胁视力性视网膜病变的最佳判别指标。在2型糖尿病患者中，血清网膜素-1浓度呈负相关，而血清Apelin和趋化素浓度与DR的存在及严重程度呈正相关。
