VIB-UGent Center for Inflammation Research, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; VIB-UGent Center for Plant Systems Biology, VIB, Ghent, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
VIB-UGent Center for Plant Systems Biology, VIB, Ghent, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
Biochem Pharmacol. 2020 May;175:113866. doi: 10.1016/j.bcp.2020.113866. Epub 2020 Feb 20.
Metabolic syndrome is characterized by the co-occurrence of diverse symptoms initiating the development of type 2 diabetes, cardiovascular diseases, and a variety of comorbid diseases. The complex constellation of numerous comorbidities makes it difficult to develop common therapeutic approaches that ameliorate these pathological features simultaneously. The plant hormones abscisic acid, salicylic acid, auxin, and cytokinins, have shown promising anti-inflammatory and pro-metabolic effects that could mitigate several disorders relevant to metabolic syndrome. Intriguingly, besides plants, human cells and gut microbes also endogenously produce these molecules, indicating a role in the complex interplay between inflammatory responses associated with metabolic syndrome, the gut microbiome, and nutrition. Here, we introduce how bioactive phytohormones can be generated endogenously and through the gut microbiome. These molecules subsequently influence immune responses and metabolism. We also elaborate on how phytohormones can beneficially modulate metabolic syndrome comorbidities, and propose them as nutraceuticals.
代谢综合征的特征是多种症状同时出现，这些症状会引发 2 型糖尿病、心血管疾病和多种合并症的发生。众多合并症的复杂组合使得开发同时改善这些病理特征的通用治疗方法变得困难。植物激素脱落酸、水杨酸、生长素和细胞分裂素具有有希望的抗炎和促进代谢作用，可以减轻与代谢综合征相关的几种疾病。有趣的是，除了植物，人类细胞和肠道微生物也内源性地产生这些分子，这表明它们在与代谢综合征相关的炎症反应、肠道微生物组和营养之间的复杂相互作用中发挥作用。在这里，我们介绍了内源性和通过肠道微生物组产生生物活性植物激素的方式。这些分子随后会影响免疫反应和代谢。我们还详细说明了植物激素如何有益地调节代谢综合征的合并症，并将它们作为营养保健品进行了探讨。
