Hua Jessica P Y, Piasecki Thomas M, McDowell Yoanna E, Boness Cassandra L, Trela Constantine J, Merrill Anne M, Sher Kenneth J, Kerns John G
Department of Psychological Sciences, University of Missouri, Columbia, MO 65211, United States; San Francisco VA Medical Center, San Francisco, CA 94121, United States.
Department of Psychological Sciences, University of Missouri, Columbia, MO 65211, United States.
Drug Alcohol Depend. 2020 Apr 1;209:107925. doi: 10.1016/j.drugalcdep.2020.107925. Epub 2020 Feb 15.
Young adulthood has the highest rates of alcohol use and high-risk drinking behavior. This period is also a critical neurodevelopmental stage, with neural insults having a profound neurotoxic effect on the brain. Cortical gyrification is thought, in part, to reflect early brain maturation (e.g., hypogyrification in fetal alcohol syndrome). There is also evidence that cortical gyrification is sensitive to later-life events (e.g., fluctuations in malnutrition in young adults). However, no study has examined how alcohol use in young adulthood is associated with cortical gyrification.
We examined the associations between cortical gyrification with lifetime alcohol use and past year hangover symptoms in young adults (N = 78).
Lifetime alcohol use was associated with hypogyria in multiple cortical regions (rs ≤ -.27, ps ≤ .0159; right orbitofrontal, right temporal pole, and left lateral occipital). Further, past year hangover symptoms were associated with hypogyria (rs ≤ -.27, ps ≤ .0034), overlapping with lifetime alcohol use (right orbitofrontal and left lateral occipital). Hangover symptoms were also uniquely associated with hypogyria of other cortical regions (rs ≤ -.30, ps ≤ .0002; right parahippocampal gyrus, left inferior temporal/parahippocampal gyrus and right anterior insula).
Thus, results suggest that young adulthood is a critical period for targeted prevention and intervention, especially for individuals exhibiting heavy alcohol consumption and high-risk drinking behavior.
青年期的酒精使用和高风险饮酒行为发生率最高。这一时期也是关键的神经发育阶段，神经损伤对大脑具有深远的神经毒性作用。皮质脑回形成部分被认为反映了早期大脑成熟（例如胎儿酒精综合征中的脑回减少）。也有证据表明皮质脑回形成对后期生活事件敏感（例如青年成年人营养不良的波动）。然而，尚无研究探讨青年期的酒精使用与皮质脑回形成之间的关联。
我们研究了青年成年人（N = 78）的皮质脑回形成与终生酒精使用及过去一年宿醉症状之间的关联。
终生酒精使用与多个皮质区域的脑回减少相关（rs ≤ -.27，ps ≤.0159；右侧眶额部、右侧颞极和左侧枕叶外侧）。此外，过去一年的宿醉症状与脑回减少相关（rs ≤ -.27，ps ≤.0034），与终生酒精使用重叠（右侧眶额部和左侧枕叶外侧）。宿醉症状还与其他皮质区域的脑回减少存在独特关联（rs ≤ -.30，ps ≤.0002；右侧海马旁回、左侧颞下/海马旁回和右侧前岛叶）。
因此，结果表明青年期是进行有针对性预防和干预的关键时期，特别是对于表现出大量饮酒和高风险饮酒行为的个体。
