Department of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
Int J Immunogenet. 2020 Oct;47(5):430-434. doi: 10.1111/iji.12482. Epub 2020 Feb 23.
Recent studies have shown participation of long non-coding RNAs (lncRNAs) in the pathogenesis of psoriasis. Several mechanisms might be involved in the dysregulation of expression of lncRNAs in patients with psoriasis, among them is the presence of single nucleotide polymorphisms (SNPs) which modulate expression or function of these transcripts. In the present work, we genotyped three SNPs (rs12826786, rs1899663 and rs4759314) of the HOX Transcript Antisense RNA (HOTAIR) in 286 patients with psoriasis and 300 control subjects. The rs12826786 was associated with risk of psoriasis in dominant model (TC + TT vs. CC: OR (95% CI) = 1.59 (0.1.14-2.22), adjusted p-value = .02). In the allelic model, T allele of this SNP significantly increased the risk of psoriasis compared with the C allele (OR (95% CI) = 1.35 (1.06-1.71), adjusted p-value = .04). Other SNPs were not associated with risk of psoriasis in any inheritance model. No significant difference was found in haplotype frequencies between cases and controls. The current work shows association between a genomic variant within HOTAIR and risk of psoriasis. The clinical significance of this finding should be assessed in future studies.
最近的研究表明，长非编码 RNA（lncRNA）参与了银屑病的发病机制。在银屑病患者中，lncRNA 表达失调的机制可能有很多，其中包括单核苷酸多态性（SNP）的存在，这些 SNP 可以调节这些转录本的表达或功能。在本研究中，我们对 286 名银屑病患者和 300 名对照者的 HOX 转录反义 RNA（HOTAIR）中的三个 SNP（rs12826786、rs1899663 和 rs4759314）进行了基因分型。rs12826786 与银屑病的发病风险在显性模型中相关（TC+TT 与 CC：OR（95%CI）=1.59（0.11-2.22），调整后的 p 值=0.02）。在等位基因模型中，与 C 等位基因相比，该 SNP 的 T 等位基因显著增加了银屑病的发病风险（OR（95%CI）=1.35（1.06-1.71），调整后的 p 值=0.04）。其他 SNP 在任何遗传模型中均与银屑病的发病风险无关。病例组和对照组之间的单倍型频率没有差异。本研究显示，HOTAIR 内的一个基因组变异与银屑病的发病风险相关。这一发现的临床意义应在未来的研究中进行评估。
