Kim In-Jai, Lee Jeong-Yong, Park Hyeon-Woo, Park Han-Sung, Ko Eun-Ju, Sung Jung-Hoon, Kim Nam-Keun
CHA Bundang Medical Center, Department of Cardiology, CHA University, Seongnam 13496, Korea.
Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Korea.
J Pers Med. 2021 May 4;11(5):375. doi: 10.3390/jpm11050375.
Coronary artery disease (CAD), one of the most frequent causes of mortality, is the most common type of cardiovascular disease. This condition is characterized by the accumulation of plaques in the coronary artery, leading to blockage of blood flow to the heart. The main symptom of CAD is chest pain caused by blockage of the coronary artery and shortness of breath. HOX transcript antisense RNA gene () is a long non-coding RNA which is well-known as an oncogene involved in various cancers, such as lung, breast, colorectal, and gastric cancer. We selected six single nucleotide polymorphisms, rs4759314 A>G, rs1899663 G>T, rs920778 T>C, rs7958904 G>C, rs12826786 C>T, and rs874945 C>T, for genotype frequency analysis and assessed the frequency of gene polymorphisms in 442 CAD patients and 418 randomly selected control subjects. To analyze the differences between these two populations, we performed a Student's -test, adjusted odds ratio (AOR), 95% confidence intervals (CIs), and ANOVA analysis. According to our baseline characteristic analysis, control subjects and CAD patients were significantly different in hypertension and diabetes mellitus. We also found that the rs4759314 A>G, rs1899663 G>T, and rs12826786 C>T genotypes were strongly associated with CAD susceptibility (AA vs. AG+GG: AOR = 0.608, 95% CI = 0.393-0.940, = 0.025; GG vs. TT: AOR = 2.276, 95% CI = 1.125-4.607, = 0.022; CC vs. CT+TT: AOR = 1.366, 95% CI = 1.027-1.818, = 0.032, respectively). Our data also demonstrated that the genotype of polymorphisms, genotype combination, and haplotype analysis affect disease occurrence. Moreover, these polymorphisms are linked to clinical factors that contribute to disease susceptibility. In conclusion, results from our study suggest that polymorphisms may be useful novel biomarkers for diagnosing CAD.
冠状动脉疾病（CAD）是最常见的心血管疾病类型之一，也是导致死亡的最常见原因之一。这种疾病的特征是冠状动脉中斑块的积累，导致心脏血流受阻。CAD的主要症状是冠状动脉阻塞引起的胸痛和呼吸急促。HOX转录本反义RNA基因（）是一种长链非编码RNA，作为一种致癌基因，参与多种癌症，如肺癌、乳腺癌、结直肠癌和胃癌。我们选择了六个单核苷酸多态性，即rs4759314 A>G、rs1899663 G>T、rs920778 T>C、rs7958904 G>C、rs12826786 C>T和rs874945 C>T，进行基因型频率分析，并评估了442例CAD患者和418例随机选择的对照受试者中该基因多态性的频率。为了分析这两个人群之间的差异，我们进行了t检验、调整后的优势比（AOR）、95%置信区间（CIs）和方差分析。根据我们的基线特征分析，对照受试者和CAD患者在高血压和糖尿病方面存在显著差异。我们还发现，rs4759314 A>G、rs1899663 G>T和rs12826786 C>T基因型与CAD易感性密切相关（AA与AG+GG相比：AOR = 0.608，95% CI = 0.393 - 0.940，P = 0.025；GG与TT相比：AOR = 2.276，95% CI =
