Rockwood E J, Anderson D R
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, FL 33101.
Graefes Arch Clin Exp Ophthalmol. 1988;226(6):510-5. doi: 10.1007/BF02169197.
In a review of fundus photographs, changes in the degree of depigmentation or atrophy of the retinal pigment epithelium (RPE) were observed near the disc over time in 21% of cases with progressive glaucomatous cupping, but they also occurred as a natural phenomenon over time in 4% of eyes with nonprogressive glaucoma and in 3% of nonglaucomatous eyes. Thus, the peripapillary RPE shows some progressive alteration in normal individuals, but also may sometimes suffer along with the axons during glaucomatous damage. The acquired changes observed in the progressive glaucomatous eyes seem too small and too infrequent to account for the high prevalence of large haloes and crescents seen around the optic disc in glaucoma.
在对眼底照片的回顾中，21%进行性青光眼性视盘凹陷的病例随着时间推移在视盘附近观察到视网膜色素上皮（RPE）色素脱失或萎缩程度的变化，但在4%的非进行性青光眼患者和3%的非青光眼患者眼中，这也作为一种自然现象随时间出现。因此，视乳头周围RPE在正常个体中显示出一些进行性改变，但在青光眼损害期间有时也可能与轴突一起受损。在进行性青光眼眼中观察到的后天性改变似乎太小且太不常见，无法解释青光眼视盘周围大光晕和半月形的高患病率。
