Hayakawa T, Sugiyama K, Tomita G, Kawase K, Onda E, Shinohara H, Tsuji A, Kitazawa Y
Department of Ophthalmology, Gifu University School of Medicine, Japan.
J Glaucoma. 1998 Oct;7(5):306-11.
To investigate the association of the peripapillary atrophy area with disc cupping area and disc hemorrhage in subjects who underwent ocular examination as part of a routine physical examination.
We reviewed plain color fundus photographs taken of 12,140 eyes of 6,070 subjects as part of a routine health examination. The refractive error in these eyes was not known. Using a computerized image analysis system, we measured the area of peripapillary atrophy (zone beta), the optic disc, and optic disc cupping by means of planimetry in 8,842 eyes of 4,421 subjects with fundus images of good quality.
The ratio of cup area to disc area was significantly greater in eyes with peripapillary atrophy (0.36 + 0.09) than in eyes without peripapillary atrophy (0.34 + 0.07), and the ratio of peripapillary atrophy area to disc area was significantly greater in eyes with disc hemorrhage (0.26 + 0.34) than in those without disc hemorrhage (0.09 + 0.18). Moreover, in eyes with peripapillary atrophy, the ratio of cup area to disc area was significantly larger in eyes with disc hemorrhage (0.48 + 0.08) than in those without disc hemorrhage (0.36 + 0.09). These results remained statistically unchanged even after "glaucomatous" eyes were excluded from the study.
Peripapillary atrophy appears to be associated with a higher degree of cupping of the optic disc and disc hemorrhage, and the results suggest an association between peripapillary atrophy and glaucomatous optic neuropathy.
在作为常规体检一部分接受眼科检查的受试者中，研究视盘周围萎缩区域与视盘杯状凹陷区域及视盘出血之间的关联。
我们回顾了作为常规健康检查一部分为6070名受试者的12140只眼睛拍摄的普通彩色眼底照片。这些眼睛的屈光不正情况未知。我们使用计算机图像分析系统，通过面积测量法在4421名具有高质量眼底图像的受试者的8842只眼睛中测量了视盘周围萎缩（β区）、视盘及视盘杯状凹陷的面积。
视盘周围萎缩的眼睛杯盘比（0.36±0.09）显著高于无视盘周围萎缩的眼睛（0.34±0.07），视盘出血的眼睛视盘周围萎缩区域与视盘面积之比（0.26±0.34）显著高于无视盘出血的眼睛（0.09±0.18）。此外，在视盘周围萎缩的眼睛中，视盘出血的眼睛杯盘比（0.48±0.08）显著大于无视盘出血的眼睛（0.36±0.09）。即使将“青光眼性”眼睛排除在研究之外，这些结果在统计学上仍无变化。
视盘周围萎缩似乎与视盘更高程度的杯状凹陷及视盘出血相关，结果提示视盘周围萎缩与青光眼性视神经病变之间存在关联。
