Rodríguez-Salgado Pamela, García-Romero María Teresa
Instituto Nacional de Pediatría, Dermatology Department, Mexico City, Mexico.
Gac Med Mex. 2019;155(5):483-491. doi: 10.24875/GMM.M20000336.
Morphea, or localized scleroderma, is a rare disease of the connective tissue that manifests itself with localized sclerosis of the skin and, in some cases, with extracutaneous manifestations. Its etiology is not fully understood, but it is believed that there is genetic predisposition, in addition to environmental triggering factors. Classification of the disease is not simple due to its multiple presentations; however, it is useful in order to define the treatment, which should be individualized and started early to avoid cosmetic and functional complications. In this review, we summarize the most important practical aspects of the classification, diagnostic methods and evaluation of morphea activity, as well as available therapeutic options, with an emphasis on existing clinical evidence regarding their efficacy and safety.
硬斑病，即局限性硬皮病，是一种罕见的结缔组织疾病，表现为皮肤局限性硬化，在某些情况下还伴有皮肤外表现。其病因尚未完全明确，但除环境触发因素外，还认为存在遗传易感性。由于该病有多种表现形式，其分类并不简单；然而，分类对于确定治疗方法很有用，治疗应个体化并尽早开始，以避免出现美容和功能方面的并发症。在本综述中，我们总结了硬斑病分类、诊断方法、活动度评估以及现有治疗选择等最重要的实际方面，重点阐述了关于其疗效和安全性的现有临床证据。
