• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

载药光敏剂-壳聚糖纳米粒子用于癌症的化疗和光动力联合治疗。

Drug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Cancer.

机构信息

Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital,N-0379 Oslo, Norway.

Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, N-0379 Oslo, Norway.

出版信息

Biomacromolecules. 2020 Apr 13;21(4):1489-1498. doi: 10.1021/acs.biomac.0c00061. Epub 2020 Mar 5.

DOI:10.1021/acs.biomac.0c00061
PMID:32092254
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7307886/
Abstract

In this study we have developed biodegradable polymeric nanoparticles (NPs) containing the cytostatic drugs mertansine (MRT) or cabazitaxel (CBZ). The NPs are based on chitosan (CS) conjugate polymers synthesized with different amounts of the photosensitizer tetraphenylchlorin (TPC). These TPC-CS NPs have high loading capacity and strong drug retention due to π-π stacking interactions between the drugs and the aromatic photosensitizer groups of the polymers. CS polymers with 10% of the side chains containing TPC were found to be optimal in terms of drug loading capacity and NP stability. The TPC-CS NPs loaded with MRT or CBZ displayed higher cytotoxicity than the free form of these drugs in the breast cancer cell lines MDA-MB-231 and MDA-MB-468. Furthermore, light-induced photochemical activation of the NPs elicited a strong photodynamic therapy effect on these breast cancer cells. Biodistribution studies in mice showed that most of the TPC-CS NPs accumulated in liver and lungs, but they were also found to be localized in tumors derived from HCT-116 cells. These data suggest that the drug-loaded TPC-CS NPs have a potential in combinatory anticancer therapy and as contrast agents.

摘要

在这项研究中，我们开发了含有细胞抑制剂美登素（MRT）或卡巴他赛（CBZ）的可生物降解聚合物纳米颗粒（NPs）。这些 NPs 基于壳聚糖（CS）共轭聚合物，这些聚合物通过不同数量的光敏剂四苯基卟啉（TPC）合成。由于药物与聚合物的芳香光敏剂基团之间的π-π堆积相互作用，这些 TPC-CS NPs 具有高载药能力和强药物保留性。在载药能力和 NP 稳定性方面，含有 10%侧链 TPC 的 CS 聚合物是最佳的。负载 MRT 或 CBZ 的 TPC-CS NPs 在乳腺癌细胞系 MDA-MB-231 和 MDA-MB-468 中显示出比游离形式更高的细胞毒性。此外，NP 的光诱导光化学激活对这些乳腺癌细胞产生了强烈的光动力治疗作用。在小鼠中的分布研究表明，大多数 TPC-CS NPs 积聚在肝脏和肺部，但也发现它们定位于源自 HCT-116 细胞的肿瘤中。这些数据表明，载药 TPC-CS NPs 在联合抗癌治疗和作为对比剂方面具有潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/e7d5563fc797/bm0c00061_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/d2ecddf1cfae/bm0c00061_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/2aee40d67fd4/bm0c00061_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/75dccaeb4ed6/bm0c00061_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/5edac34a8633/bm0c00061_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/5aac0488b3ac/bm0c00061_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/b7dbf3d0d386/bm0c00061_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/ea178b35d9a9/bm0c00061_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/4b24067a8b17/bm0c00061_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/e7d5563fc797/bm0c00061_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/d2ecddf1cfae/bm0c00061_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/2aee40d67fd4/bm0c00061_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/75dccaeb4ed6/bm0c00061_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/5edac34a8633/bm0c00061_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/5aac0488b3ac/bm0c00061_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/b7dbf3d0d386/bm0c00061_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/ea178b35d9a9/bm0c00061_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/4b24067a8b17/bm0c00061_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3709/7307886/e7d5563fc797/bm0c00061_0009.jpg

相似文献

1
Drug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Cancer.载药光敏剂-壳聚糖纳米粒子用于癌症的化疗和光动力联合治疗。
Biomacromolecules. 2020 Apr 13;21(4):1489-1498. doi: 10.1021/acs.biomac.0c00061. Epub 2020 Mar 5.
2
Construction of pH/glutathione responsive chitosan nanoparticles by a self-assembly/self-crosslinking method for photodynamic therapy.通过自组装/自交联法构建 pH/谷胱甘肽响应性壳聚糖纳米粒子用于光动力治疗。
Int J Biol Macromol. 2021 Jan 15;167:46-58. doi: 10.1016/j.ijbiomac.2020.11.141. Epub 2020 Nov 30.
3
Co-delivery of Docetaxel and Disulfonate Tetraphenyl Chlorin in One Nanoparticle Produces Strong Synergism between Chemo- and Photodynamic Therapy in Drug-Sensitive and -Resistant Cancer Cells.载多西他赛与二磺酸钠四苯基卟啉的纳米粒子共递送在耐药和敏感癌细胞的化疗和光动力治疗中产生强烈协同作用。
Mol Pharm. 2018 Oct 1;15(10):4599-4611. doi: 10.1021/acs.molpharmaceut.8b00597. Epub 2018 Sep 7.
4
In vitro and in vivo anticancer efficacy potential of Quercetin loaded polymeric nanoparticles.载槲皮素聚合物纳米粒的体外及体内抗癌功效研究。
Biomed Pharmacother. 2018 Oct;106:1513-1526. doi: 10.1016/j.biopha.2018.07.106. Epub 2018 Jul 25.
5
Actively targeting D-α-tocopheryl polyethylene glycol 1000 succinate-poly(lactic acid) nanoparticles as vesicles for chemo-photodynamic combination therapy of doxorubicin-resistant breast cancer.主动靶向D-α-生育酚聚乙二醇1000琥珀酸酯-聚乳酸纳米粒作为载体用于多柔比星耐药乳腺癌的化学-光动力联合治疗
Nanoscale. 2016 Feb 7;8(5):3100-18. doi: 10.1039/c5nr07724a.
6
Biodegradable core-shell nanoassemblies for the delivery of docetaxel and Zn(II)-phthalocyanine inspired by combination therapy for cancer.基于癌症联合治疗的灵感，用于递送多西他赛和 Zn(II)-酞菁的可生物降解核壳纳米组装体。
J Control Release. 2013 Apr 10;167(1):40-52. doi: 10.1016/j.jconrel.2012.12.026. Epub 2013 Jan 5.
7
pH-responsive and self-targeting assembly from hyaluronic acid-based conjugate toward all-in-one chemo-photodynamic therapy.基于透明质酸的共轭物的 pH 响应性和自靶向组装用于一体式化学-光动力治疗。
J Colloid Interface Sci. 2019 Jul 1;547:30-39. doi: 10.1016/j.jcis.2019.03.087. Epub 2019 Mar 26.
8
Water-Soluble, Zwitterionic Poly-photosensitizers as Carrier-Free, Photosensitizer-Self-Delivery System for in Vivo Photodynamic Therapy.水溶性两性离子多光增敏剂作为无载体、光增敏剂自递药系统用于体内光动力治疗。
ACS Appl Mater Interfaces. 2019 Nov 27;11(47):44007-44017. doi: 10.1021/acsami.9b19546. Epub 2019 Nov 19.
9
Tumor microenvironment triple-responsive nanoparticles enable enhanced tumor penetration and synergetic chemo-photodynamic therapy.肿瘤微环境三响应性纳米粒子增强肿瘤穿透并协同化学生物动力学治疗。
Biomaterials. 2021 Jan;268:120574. doi: 10.1016/j.biomaterials.2020.120574. Epub 2020 Nov 25.
10
Tumor-homing photosensitizer-conjugated glycol chitosan nanoparticles for synchronous photodynamic imaging and therapy based on cellular on/off system.基于细胞开/关系统的肿瘤归巢型光敏剂偶联壳聚糖纳米粒用于同步光动力学成像和治疗。
Biomaterials. 2011 Jun;32(16):4021-9. doi: 10.1016/j.biomaterials.2011.02.009. Epub 2011 Mar 3.

引用本文的文献

1
Encapsulation of Curcumin and Gemcitabine: Cytotoxic Effect and Mechanisms of Death in Lung Cancer.姜黄素与吉西他滨的包封：对肺癌的细胞毒性作用及死亡机制
Adv Pharmacol Pharm Sci. 2025 Aug 13;2025:8816364. doi: 10.1155/adpp/8816364. eCollection 2025.
2
Functional hydrogel empowering 3D printing titanium alloys.功能水凝胶助力3D打印钛合金。
Mater Today Bio. 2024 Dec 24;30:101422. doi: 10.1016/j.mtbio.2024.101422. eCollection 2025 Feb.
3
Drug Loading in Chitosan-Based Nanoparticles.基于壳聚糖的纳米颗粒中的药物负载

本文引用的文献

1
Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research.用于细胞内药物递送的光化学内化：从基本机制到临床研究
J Clin Med. 2020 Feb 14;9(2):528. doi: 10.3390/jcm9020528.
2
Biological response and cytotoxicity induced by lipid nanocapsules.脂质纳米胶囊诱导的生物反应和细胞毒性。
J Nanobiotechnology. 2020 Jan 6;18(1):5. doi: 10.1186/s12951-019-0567-y.
3
Sinoporphyrin Sodium-Mediated Sonodynamic Therapy Inhibits RIP3 Expression and Induces Apoptosis in the H446 Small Cell Lung Cancer Cell Line.
Pharmaceutics. 2024 Aug 6;16(8):1043. doi: 10.3390/pharmaceutics16081043.
4
Nanocarriers Loaded with Danshensu for Treating Ischemic Stroke by Reducing Oxidative Stress and Glial Overactivation.负载丹酚酸的纳米载体通过减轻氧化应激和神经胶质细胞过度激活治疗缺血性中风
ACS Omega. 2024 Aug 5;9(33):35686-35694. doi: 10.1021/acsomega.4c03991. eCollection 2024 Aug 20.
5
Entry of nanoparticles into cells and tissues: status and challenges.纳米颗粒进入细胞和组织：现状与挑战。
Beilstein J Nanotechnol. 2024 Aug 12;15:1017-1029. doi: 10.3762/bjnano.15.83. eCollection 2024.
6
Hydroxychloroquine-Loaded Chitosan Nanoparticles Induce Anticancer Activity in A549 Lung Cancer Cells: Design, BSA Binding, Molecular Docking, Mechanistic, and Biological Evaluation.载羟氯喹壳聚糖纳米粒诱导 A549 肺癌细胞的抗癌活性：设计、BSA 结合、分子对接、机制和生物学评价。
Int J Mol Sci. 2023 Sep 14;24(18):14103. doi: 10.3390/ijms241814103.
7
Polyurethane-based nanofibrous mat containing porphyrin with photosensitivity and bactericidal properties can promote cutaneous tissue healing in rats.含光敏性和杀菌性能卟啉的聚氨酯基纳米纤维垫可促进大鼠皮肤组织愈合。
J Nanobiotechnology. 2023 Sep 4;21(1):313. doi: 10.1186/s12951-023-02082-z.
8
Chitosan-Based Nanoparticles with Optimized Parameters for Targeted Delivery of a Specific Anticancer Drug-A Comprehensive Review.具有优化参数的基于壳聚糖的纳米颗粒用于特定抗癌药物的靶向递送——综述
Pharmaceutics. 2023 Feb 2;15(2):503. doi: 10.3390/pharmaceutics15020503.
9
Nanoparticles and Nanomaterials-Based Recent Approaches in Upgraded Targeting and Management of Cancer: A Review.基于纳米颗粒和纳米材料的癌症靶向与管理最新进展综述
Cancers (Basel). 2022 Dec 27;15(1):162. doi: 10.3390/cancers15010162.
10
Tumor microenvironment penetrating chitosan nanoparticles for elimination of cancer relapse and minimal residual disease.肿瘤微环境穿透性壳聚糖纳米颗粒用于消除癌症复发和最小残留疾病
Front Oncol. 2022 Nov 30;12:1054029. doi: 10.3389/fonc.2022.1054029. eCollection 2022.
血卟啉单甲醚介导的声动力疗法抑制H446小细胞肺癌细胞系中RIP3表达并诱导细胞凋亡。
Cell Physiol Biochem. 2018;51(6):2938-2954. doi: 10.1159/000496045. Epub 2018 Dec 14.
4
Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft.载紫杉醇聚（2-乙基丁基氰基丙烯酸酯）纳米粒改善患者来源乳腺癌异种移植模型的治疗效果。
J Control Release. 2019 Jan 10;293:183-192. doi: 10.1016/j.jconrel.2018.11.029. Epub 2018 Dec 4.
5
RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer.RSL3通过使GPX4失活和在结直肠癌中产生活性氧来驱动铁死亡。
Front Pharmacol. 2018 Nov 22;9:1371. doi: 10.3389/fphar.2018.01371. eCollection 2018.
6
Recent advances in nanoparticle carriers for photodynamic therapy.用于光动力疗法的纳米颗粒载体的最新进展。
Quant Imaging Med Surg. 2018 May;8(4):433-443. doi: 10.21037/qims.2018.05.04.
7
Photochemical Internalization of Peptide Antigens Provides a Novel Strategy to Realize Therapeutic Cancer Vaccination.肽抗原的光化学内化提供了实现治疗性癌症免疫接种的新策略。
Front Immunol. 2018 Apr 4;9:650. doi: 10.3389/fimmu.2018.00650. eCollection 2018.
8
FINO initiates ferroptosis through GPX4 inactivation and iron oxidation.FINO 通过 GPX4 失活和铁氧化引发铁死亡。
Nat Chem Biol. 2018 May;14(5):507-515. doi: 10.1038/s41589-018-0031-6. Epub 2018 Apr 2.
9
Antimicrobial Chitosan and Chitosan Derivatives: A Review of the Structure-Activity Relationship.抗菌壳聚糖及其衍生物：结构-活性关系综述。
Biomacromolecules. 2017 Nov 13;18(11):3846-3868. doi: 10.1021/acs.biomac.7b01058. Epub 2017 Oct 3.
10
A triple-synergistic strategy for combinational photo/radiotherapy and multi-modality imaging based on hyaluronic acid-hybridized polyaniline-coated WS nanodots.基于透明质酸杂交聚苯胺包覆 WS 纳米点的三联增效策略用于联合光/放射治疗和多模态成像。
Nanoscale. 2017 May 4;9(17):5551-5564. doi: 10.1039/c6nr09219e.