Department of Biology, University of Washington, Seattle, Washington 98195, USA; email:
Annu Rev Plant Biol. 2020 Apr 29;71:767-788. doi: 10.1146/annurev-arplant-081519-035852. Epub 2020 Feb 24.
Synthetic signaling is a branch of synthetic biology that aims to understand native genetic regulatory mechanisms and to use these insights to engineer interventions and devices that achieve specified design parameters. Applying synthetic signaling approaches to plants offers the promise of mitigating the worst effects of climate change and providing a means to engineer crops for entirely novel environments, such as those in space travel. The ability to engineer new traits using synthetic signaling methods will require standardized libraries of biological parts and methods to assemble them; the decoupling of complex processes into simpler subsystems; and mathematical models that can accelerate the design-build-test-learn cycle. The field of plant synthetic signaling is relatively new, but it is poised for rapid advancement. Translation from the laboratory to the field is likely to be slowed, however, by the lack of constructive dialogue between researchers and other stakeholders.
合成信号转导是合成生物学的一个分支，旨在理解天然的遗传调控机制，并利用这些见解来设计干预措施和设备，以实现特定的设计参数。将合成信号转导方法应用于植物有望减轻气候变化的最坏影响，并为完全新颖的环境（例如太空旅行中的环境）设计农作物提供一种手段。使用合成信号转导方法设计新性状的能力将需要标准化的生物部件库和组装它们的方法；将复杂过程解耦为更简单的子系统；以及可以加速设计-构建-测试-学习周期的数学模型。植物合成信号转导领域相对较新，但它有望迅速发展。然而，由于研究人员和其他利益相关者之间缺乏建设性的对话，从实验室到实地的转化可能会放缓。
