Pichler Alexander, Sellner Johann, Harutyunyan Gayane, Sonnleitner Astrid, Klobassa Daniela Sabine, Archelos-Garcia Juan-Jose, Rock Hannah, Gattringer Thomas, Fazekas Franz
Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria.
Department of Neurology, Paracelsus Medical University of Salzburg, Ignaz-Harrer-Straße 79, 5020 Salzburg, Austria.
J Neurol Sci. 2017 Apr 15;375:266-269. doi: 10.1016/j.jns.2017.02.003. Epub 2017 Feb 3.
Magnetic resonance imaging (MRI) in tick-borne encephalitis (TBE) is often performed for differential diagnosis, but only a few reports on the morphologic changes in TBE patients and their relation to the disease severity exist.
We retrospectively searched for all TBE patients who were admitted to the Departments of Neurology of the Medical University of Graz (Austria) and the Paracelsus Medical University of Salzburg (Austria) between 2003 and 2014. We recorded the clinical and demographic variables and rated overall disease severity as mild, moderate, severe or leading to death due to TBE. MRI scans were screened for morphologic abnormalities.
Of an initial cohort of 88 patients with TBE, 45 patients with an available MRI of the brain were included in this study (median age 58.0years, range: 18-80; men n=28). Their median time spent in the hospital was 18days (range: 4-174days). 16 patients had a mild, 18 a moderate and 10 a severe disease course. One patient died due to TBE. TBE related brain abnormalities could be identified in 4 cases. They consisted of diffuse areas of T2-signal hyperintensity, which were located in the crura cerebri in three patients and in the right centrum semiovale in one patient. No contrast enhancement was observed in any of the lesions and their presence was not related to specific clinical findings or the severity of TBE.
MRI brain lesions in TBE are rare and do not correlate with the course of the disease. Diffuse areas of signal hyperintensity in the crura cerebri appear suggestive of TBE.
蜱传脑炎（TBE）的磁共振成像（MRI）常用于鉴别诊断，但关于TBE患者形态学变化及其与疾病严重程度关系的报道较少。
我们回顾性检索了2003年至2014年间奥地利格拉茨医科大学和萨尔茨堡帕拉塞尔苏斯医科大学神经科收治的所有TBE患者。记录临床和人口统计学变量，并将总体疾病严重程度评定为轻度、中度、重度或因TBE导致死亡。对MRI扫描进行形态学异常筛查。
最初的88例TBE患者中，本研究纳入了45例有脑部MRI资料的患者（中位年龄58.0岁，范围：18 - 80岁；男性n = 28）。他们在医院的中位住院时间为18天（范围：4 - 174天）。16例患者病程为轻度，18例为中度，10例为重度。1例患者死于TBE。4例患者可发现与TBE相关的脑部异常。表现为T2信号高的弥漫性区域，其中3例位于大脑脚，1例位于右侧半卵圆中心。所有病变均未观察到强化，其存在与特定临床发现或TBE严重程度无关。
TBE的脑部MRI病变罕见，且与疾病病程无关。大脑脚信号高的弥漫性区域提示TBE。
