Wei Xiaomin, Yang Fuzhen, Chen Defang, Li Jun, Shi Xiaohong, Li Buran, Zhang Chunling
Department of Outpatient, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, People's Republic of China.
Department of Medical Imaging, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, People's Republic of China.
Toxicol Ind Health. 2020 Jan;36(1):22-29. doi: 10.1177/0748233719900844.
In recent years, nanoparticles have been widely used in many fields, ranging from cosmetics, agriculture, environment, and biomedical areas. The increasing use of nanoproducts induces a potential increasing exposure to human body, and then, unknown pathological consequences could increase.
The database was searched from 2008 to 2018 by the Web of Science Core Collection. The bibliometric methods, CiteSpace and HistCite, were used for analysis and visualization of the data.
The 2932 publications were analyzed and the annual publications grew from 78 to 512 in a decade. The United States and China mainly contribute to this research area, which accounted for 29.5% and 22.9%, respectively. , , and were the three journals that published the most articles. Keyword analysis indicated that the major research direction was the mechanisms of nanoneurotoxicity, which included oxidative stress, inflammation, astrocyte activation, and the fibrillation of amyloid β protein.
This bibliometric study revealed that nanoneurotoxicity was still a research hot topic and could be a promising area of research in the next few years. Nanoparticles play a role in neurodegenerative diseases by inducing reactive oxygen species production, inflammation, alterations of gene expression, and signal pathways.
近年来，纳米颗粒已广泛应用于许多领域，包括化妆品、农业、环境和生物医学领域。纳米产品使用的增加导致人体潜在暴露增加，进而可能增加未知的病理后果。
通过科学网核心合集检索2008年至2018年的数据库。使用文献计量学方法CiteSpace和HistCite对数据进行分析和可视化。
对2932篇出版物进行了分析，十年间年出版物数量从78篇增长到512篇。美国和中国对该研究领域贡献最大，分别占29.5%和22.9%。《 》《 》和《 》是发表文章最多的三本期刊。关键词分析表明，主要研究方向是纳米神经毒性机制，包括氧化应激、炎症、星形胶质细胞活化和淀粉样β蛋白的纤维化。
这项文献计量学研究表明，纳米神经毒性仍然是一个研究热点，并且可能是未来几年一个有前景的研究领域。纳米颗粒通过诱导活性氧生成、炎症、基因表达改变和信号通路在神经退行性疾病中发挥作用。
