Institute for Integrative Nanosciences, Leibniz IFW Dresden, Helmholtzstraße 20, 01069 Dresden, Germany.
Research Center for Materials, Architectures and Integration of Nanomembranes (MAIN), TU Chemnitz, Rosenbergstraße 6, 09126 Chemnitz, Germany.
ACS Nano. 2020 Mar 24;14(3):2982-2993. doi: 10.1021/acsnano.9b07851. Epub 2020 Mar 4.
Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo delivery in complex biological environments. However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood. Here we present a hybrid sperm micromotor that can actively swim against flowing blood (continuous and pulsatile) and perform the function of heparin cargo delivery. In this biohybrid system, the sperm flagellum provides a high propulsion force while the synthetic microstructure serves for magnetic guidance and cargo transport. Moreover, single sperm micromotors can assemble into a train-like carrier after magnetization, allowing the transport of multiple sperm or medical cargoes to the area of interest, serving as potential anticoagulant agents to treat blood clots or other diseases in the circulatory system.
微马达被认为是在复杂的生物环境中进行无绳微操作和靶向货物输送的有前途的候选者。然而，由于许多报道的合成微马达所表现出的低推力，它们在循环系统中的可行性受到限制，因为这种低推力不足以克服血液的高流速和复杂成分。在这里，我们提出了一种混合的精子微马达，它可以主动对抗流动的血液（连续的和脉动的）并执行肝素货物输送的功能。在这个生物混合系统中，精子鞭毛提供了一个高推进力，而合成的微结构则用于磁导向和货物运输。此外，单个精子微马达在磁化后可以组装成一列类似火车的载体，从而允许将多个精子或医疗货物输送到感兴趣的区域，作为潜在的抗凝剂来治疗循环系统中的血栓或其他疾病。
