Xin Hongbao, Zhao Nan, Wang Yunuo, Zhao Xiaoting, Pan Ting, Shi Yang, Li Baojun
Institute of Nanophotonics, Jinan University, Guangzhou 511443, China.
Department of Nephrology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Nano Lett. 2020 Oct 14;20(10):7177-7185. doi: 10.1021/acs.nanolett.0c02501. Epub 2020 Sep 18.
Bioinspired and biohybrid micromotors represent a revolution in microrobotic research and are playing an increasingly important role in biomedical applications. In particular, biological micromotors that are multifunctional and can perform complex tasks are in great demand. Here, we report living and multifunctional micromotors based on single cells (green microalgae: ) that are controlled by optical force. The micromotor's locomotion can be carefully controlled in a variety of biological media including cell culture medium, saliva, human serum, plasma, blood, and bone marrow fluid. It exhibits the capabilities to perform multiple tasks, in particular, indirect manipulation of biological targets and disruption of biological aggregates including in vitro blood clots. These micromotors can also act as elements in reconfigurable motor arrays where they efficiently work collaboratively and synchronously. This work provides new possibilities for many in vitro biomedical applications including target manipulation, cargo delivery and release, and biological aggregate removal.
受生物启发的和生物杂交的微马达代表了微机器人研究的一场革命，并且在生物医学应用中发挥着越来越重要的作用。特别是，对多功能且能执行复杂任务的生物微马达有巨大需求。在此，我们报道基于单细胞（绿色微藻： ）的活体多功能微马达，其由光力控制。该微马达的运动可在多种生物介质中得到精确控制，包括细胞培养基、唾液、人血清、血浆、血液和骨髓液。它展现出执行多种任务的能力，特别是对生物靶点的间接操控以及对包括体外血凝块在内的生物聚集体的破坏。这些微马达还可作为可重构马达阵列中的元件，在其中它们能高效地协同和同步工作。这项工作为许多体外生物医学应用提供了新的可能性，包括靶点操控、货物递送与释放以及生物聚集体清除。
