Borgonovo Gigliola, De Petrocellis Luciano, Schiano Moriello Aniello, Bertoli Simona, Leone Alessandro, Battezzati Alberto, Mazzini Stefania, Bassoli Angela
Department of Food, Environment and Nutrition-DeFENS, University of Milan, Via Celoria 2, I-20133 Milano, Italy.
Endocannabinoid Research Group-Institute of Biomolecular Chemistry-CNR, Pozzuoli, I-87078 Napoli, Italy.
Molecules. 2020 Feb 22;25(4):976. doi: 10.3390/molecules25040976.
Lam. is a tropical plant widely used in traditional medicines and as a food supplement. It is characterized by the presence of glucosinolates and isothiocyanates; the stable isothiocyanate 4-[(α-l-rhamnosyloxy)benzyl]isothiocyanate (moringin) has been widely studied for its bioactivity as hypoglycemic, antimicrobial, anticancer and in particular for its involvement in nociception and neurogenic pain. Moringa extracts and pure moringin were submitted to in vitro assays with the somatosensory TRPA1 ion channel, proving that moringin is a potent and effective agonist of this receptor involved in nociceptive function and pain states. Moringin do not activate or activates very weakly the vanilloids somatosensory channels TRPV1,2,3 and 4, and the melastatin cooling receptor TRPM8. The comparison of moringin's activity with other known agonists of natural origin is also discussed.
辣木是一种热带植物，广泛用于传统医学和作为食品补充剂。它的特点是含有硫代葡萄糖苷和异硫氰酸酯；稳定的异硫氰酸酯4-[(α-L-鼠李糖氧基)苄基]异硫氰酸酯（辣木素）因其降血糖、抗菌、抗癌的生物活性，特别是因其在伤害感受和神经源性疼痛中的作用而受到广泛研究。辣木提取物和纯辣木素用躯体感觉TRPA1离子通道进行了体外试验，证明辣木素是该参与伤害感受功能和疼痛状态的受体的有效激动剂。辣木素不会激活或非常微弱地激活香草酸躯体感觉通道TRPV1、2、3和4，以及褪黑素冷却受体TRPM8。还讨论了辣木素与其他已知天然激动剂的活性比较。
