International Center for the Assessment of Nutritional Status (ICANS), University of Milan, Via Sandro Botticelli 21, 20133 Milan, Italy.
Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Via Luigi Mangiagalli 25, 20133 Milan, Italy.
Nutrients. 2018 Oct 12;10(10):1494. doi: 10.3390/nu10101494.
The hypoglycemic effect in humans of (MO) leaf powder has, to date, been poorly investigated. We assessed the chemical composition of MO leaf powder produced at Saharawi refugee camps, its in vitro ability to inhibit α-amylase activity, and its sensory acceptability in food. We then evaluated its effect on postprandial glucose response by randomly administering, on 2 different days, a traditional meal supplemented with 20 g of MO leaf powder (MOR20), or not (control meal, CNT), to 17 Saharawi diabetics and 10 healthy subjects. Capillary glycaemia was measured immediately before the meal and then at 30 min intervals for 3 h. In the diabetic subjects the postprandial glucose response peaked earlier with MOR20 compared to CNT and with lower increments at 90, 120, and 150 min. The mean glycemic meal response with MOR20 was lower than with CNT. The healthy subjects showed no differences. Thus, MO leaf powder could be a hypoglycemic herbal drug. However, given the poor taste acceptability of the 20 g MO meal, lower doses should be evaluated. Moreover, the hypoglycemic effects of MO leaf powder should also be demonstrated by trials evaluating its long-term effects on glycaemia.
到目前为止，（MO）叶粉在人体中的降血糖作用研究甚少。我们评估了在撒哈拉难民营生产的 MO 叶粉的化学成分、体外抑制α-淀粉酶活性的能力及其在食品中的感官可接受性。然后，我们通过在 2 天的不同时间随机给 17 名撒哈拉糖尿病患者和 10 名健康受试者服用补充 20 克 MO 叶粉的传统餐（MOR20）或不补充（对照餐，CNT），评估其对餐后血糖反应的影响。在餐前和餐后 30 分钟间隔测量毛细血管血糖，共 3 小时。与 CNT 相比，MOR20 使糖尿病患者的餐后血糖峰值更早出现，90、120 和 150 分钟时的增量更低。MOR20 的平均血糖反应低于 CNT。健康受试者没有差异。因此，MO 叶粉可能是一种降血糖草药。然而，由于 20 克 MO 餐的口感较差，应评估较低剂量。此外，还应通过评估 MO 叶粉对血糖的长期影响的试验来证明其降血糖作用。
