Cullman Chemoprotection Center, Johns Hopkins University, Baltimore, MD 21205, USA.
Department of Medicine, Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Nutrients. 2019 Jul 9;11(7):1547. doi: 10.3390/nu11071547.
The tropical tree produces high yields of protein-rich leaf biomass, is widely used as a food source, contains an abundance of phytochemicals, and thus has great potential for chronic disease prevention and perhaps, treatment. We have developed and characterized standardized ways of preparing aqueous "teas" from moringa leaves to deliver precisely calibrated levels of phytochemicals for use in clinical trials. These phytochemicals, especially the glucosinolate glucomoringin and the isothiocyanate moringin, produced from it following hydrolysis by the enzyme myrosinase, provide potent anti-inflammatory and cytoprotective indirect antioxidant activity. The taste of both hot and cold teas is palatable without the need for flavor masking. These teas can be easily and reproducibly prepared in underserved tropical regions of the world where moringa is cultivated. Isothiocyanate yield from a cold extraction was rapid and essentially complete after 30 min and its anti-inflammatory potential is comparable to that of equimolar purified moringin. A preparation similar to this may be safe to consume with respect to its bacterial titer even after 48 h without refrigeration. Thus, facile delivery of moringa tea to both adults and children for clinical evaluation of their effects on such conditions as autism, diabetes, and hypertension, is now possible.
这种热带树木的叶子能产出高蛋白质、高生物量，它被广泛用作食物来源，含有丰富的植物化学物质，因此具有预防慢性病的巨大潜力，也许还能用于慢性病的治疗。我们已经开发出并规范了从辣木叶中提取水浸“茶”的方法，这种茶可以精确地提供植物化学物质，用于临床试验。这些植物化学物质，特别是辣木叶酶解后产生的葡萄糖苷辣木素和异硫氰酸酯萝卜硫素，具有很强的抗炎和细胞保护间接抗氧化活性。热饮和冷饮的味道都很好，不需要用香料来掩盖。这些茶可以在辣木种植的欠发达热带地区轻松且可重复地制备。在 30 分钟后，从冷浸中提取的异硫氰酸酯迅速且几乎完全提取出来，其抗炎潜力与等摩尔纯化的萝卜硫素相当。这种类似的制剂在没有冷藏的情况下，即使放置 48 小时后，其细菌含量仍可能是安全的，可以用于成人和儿童的临床试验，以评估其对自闭症、糖尿病和高血压等疾病的影响。
