包括使用下一代测序技术和蛋白质组学发现的因素在内的致病性和毒力因子。
Pathogenicity and Virulence Factors of Including Factors Discovered Using Next Generation Sequencing Technologies and Proteomics.
作者信息
Rauwane Molemi E, Ogugua Udoka V, Kalu Chimdi M, Ledwaba Lesiba K, Woldesemayat Adugna A, Ntushelo Khayalethu
机构信息
Department of Agriculture and Animal Health, Science Campus, University of South Africa, Corner Christiaan de Wet Road and Pioneer Avenue, Private Bag X6, Florida 1710, South Africa.
Agricultural Research Council-Vegetable and Ornamental Plants (ARC-VOP), Plant Breeding Division, Roodeplaat, Private Bag X293, Pretoria 0001, South Africa.
出版信息
Microorganisms. 2020 Feb 22;8(2):305. doi: 10.3390/microorganisms8020305.
is a devasting mycotoxin-producing pathogen of grain crops. has been extensively studied to understand its pathogenicity and virulence factors. These studies gained momentum with the advent of next-generation sequencing (NGS) technologies and proteomics. NGS and proteomics have enabled the discovery of a multitude of pathogenicity and virulence factors of . This current review aimed to trace progress made in discovering pathogenicity and virulence factors in general, as well as pathogenicity and virulence factors discovered using NGS, and to some extent, using proteomics. We present more than 100 discovered pathogenicity or virulence factors and conclude that although a multitude of pathogenicity and virulence factors have already been discovered, more work needs to be done to take advantage of NGS and its companion applications of proteomics.
是一种对谷物作物具有毁灭性的产真菌毒素病原体。人们对其进行了广泛研究以了解其致病性和毒力因子。随着下一代测序（NGS）技术和蛋白质组学的出现，这些研究得到了进一步推动。NGS和蛋白质组学使得能够发现的大量致病性和毒力因子。本综述旨在追踪在发现一般致病性和毒力因子方面所取得的进展，以及利用NGS乃至在一定程度上利用蛋白质组学发现的致病性和毒力因子。我们展示了100多个已发现的致病性或毒力因子，并得出结论，尽管已经发现了大量致病性和毒力因子，但仍需开展更多工作以利用NGS及其配套的蛋白质组学应用。
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