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: Magnesium is involved in a wide variety of physiological processes including direct relaxation of smooth muscle. A magnesium imbalance can be considered the primary cause or consequence of many pathophysiological conditions. The smooth muscle tissue of the uterus, i.e., the myometrium, undergoes numerous physiological changes during life, fundamental for uterine activities, and it receives proven benefits from magnesium supplementation. However, magnesium supplements have poor absorption and bioavailability. Furthermore, no data are available on the direct interaction between intestinal absorption of magnesium and relaxation of the myometrium. : Permeability in human intestinal cells (Caco-2 cells) and direct effects on myometrial cells (PHM1-41 cells) of two different forms of magnesium, i.e., sucrosomial and bisglycinate, were studied in order to verify the magnesium capacity of modulate contractility. Cell viability, reactive oxygen species (ROS) and nitric oxide (NO) production, magnesium concentration, contractility, and pathways involved were analyzed. : Data showed a better influence of buffered chelate bisglycinate on intestinal permeability and myometrial relaxation over time with a maximum effect at 3 h and greater availability compared to the sucrosomial form. : Magnesium-buffered bisglycinate chelate showed better intestinal absorption and myometrial contraction, indicating a better chance of effectiveness in human applications.

镁参与多种生理过程，包括平滑肌的直接松弛。镁失衡可被视为许多病理生理状况的主要原因或后果。子宫的平滑肌组织，即子宫肌，在其一生中经历了许多生理变化，这些变化是子宫活动的基础，并且已被证明补充镁有好处。然而，镁补充剂的吸收和生物利用度较差。此外，尚无关于肠道吸收镁与子宫平滑肌松弛之间直接相互作用的资料。

本研究旨在验证两种不同形式的镁，即蔗糖酯和双甘氨酸镁，对人肠细胞（Caco-2 细胞）的通透性和对子宫平滑肌细胞（PHM1-41 细胞）的直接作用，以验证镁调节收缩性的能力。分析了细胞活力、活性氧（ROS）和一氧化氮（NO）的产生、镁浓度、收缩性以及涉及的途径。

数据显示，缓冲螯合双甘氨酸镁对肠通透性和子宫平滑肌松弛的影响随着时间的推移更好，在 3 小时时达到最大效果，并且与蔗糖酯形式相比更具可用性。

镁缓冲双甘氨酸螯合物显示出更好的肠道吸收和子宫收缩性，表明在人体应用中更有可能有效。