Funakoshi A, Wakasugi H, Ibayashi H
Gastroenterol Jpn. 1979 Oct;14(5):436-40. doi: 10.1007/BF02773731.
Serum Deoxyribonuclease (DNase) of normal persons and of patients with chronic pancreatitis, pancreatic cancer, Diabetes Mellitus, or other malignant diseases was determined with (32P) DNA as substrate. Serum DNase activity was much lower in patients with chronic pancreatitis, pancreatic cancer, or other malignant diseases than in control subjects, and serum DNase activity was almost normal in patients with Diabetes Mellitus. There was no correlation between serum DNase and serum amylase, but there was a good correlation between serum DNase and DNase I output in duodenal juice. There was an inverse correlation between serum DNase and serum RNase. These results imply that in the diagnosis of possible pancreatic disorders serum DNase may be a good indicator and thus may be useful for the detection of malignant diseases.
以（32P）DNA为底物，测定了正常人和慢性胰腺炎、胰腺癌、糖尿病或其他恶性疾病患者的血清脱氧核糖核酸酶（DNase）。慢性胰腺炎、胰腺癌或其他恶性疾病患者的血清DNase活性远低于对照组，而糖尿病患者的血清DNase活性几乎正常。血清DNase与血清淀粉酶之间无相关性，但血清DNase与十二指肠液中DNase I的分泌量之间有良好的相关性。血清DNase与血清核糖核酸酶（RNase）呈负相关。这些结果表明，在可能的胰腺疾病诊断中，血清DNase可能是一个良好的指标，因此可能有助于恶性疾病的检测。
