Basso D, Fabris C, Meani A, Del Favero G, Panucci A, Vianello D, Piccoli A, Naccarato R
Tumori. 1985 Dec 31;71(6):529-32. doi: 10.1177/030089168507100602.
Serum ribonuclease (RNase) and deoxyribonuclease (DNase) were investigated in 18 control subjects, and in 22 patients with pancreatic cancer, 13 with chronic pancreatitis and 29 with extrapancreatic diseases in order to assess their clinical usefulness in pancreatic cancer diagnosis and to evaluate whether modifications were consensual and/or age-related. Increased DNase and RNase values were found not only in a notable proportion of pancreatic cancer, but also in chronic pancreatitis and extra-pancreatic diseases. Thus the clinical value of both enzymes in pancreatic cancer diagnosis is negligible. DNase does not seem to be strictly age-dependent, whereas serum RNase does. Elevated levels of the two enzymes, when present, were consensual, suggesting that factors involved in such an increase were partially common to both.
对18名对照受试者、22名胰腺癌患者、13名慢性胰腺炎患者和29名胰腺外疾病患者的血清核糖核酸酶（RNase）和脱氧核糖核酸酶（DNase）进行了研究，以评估它们在胰腺癌诊断中的临床实用性，并评估这些改变是否与年龄相关以及是否具有一致性。不仅在相当比例的胰腺癌患者中发现DNase和RNase值升高，在慢性胰腺炎和胰腺外疾病患者中也有发现。因此，这两种酶在胰腺癌诊断中的临床价值可忽略不计。DNase似乎并非严格依赖年龄，而血清RNase则与年龄有关。当两种酶水平升高时，具有一致性，这表明导致这种升高的因素部分是相同的。
